A0A0K0E0I7 protein (Strongyloides stercoralis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A0K0E0I7

Uncharacterized protein. (374 aa)

Predicted Functional Partners:

A0A0K0DUA1

0.999

A0A0K0DXQ0

0.999

A0A0K0EKY3

0.999

A0A0K0EQQ2

0.999

A0A0K0DUI9

0.998

A0A0K0DW02

0.998

A0A0K0E0N1

0.998

A0A0K0DVH7

0.997

A0A0K0EQY0

0.997

A0A0K0ETG9

0.997

Your Current Organism:

Strongyloides stercoralis

NCBI taxonomy Id: 6248
Other names: S. stercoralis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0K0DUA1	A0A0K0DUI9	Utp12 domain-containing protein.	BP28CT domain-containing protein.	0.999
A0A0K0DUA1	A0A0K0DVH7	Utp12 domain-containing protein.	CBF domain-containing protein.	0.999
A0A0K0DUA1	A0A0K0DW02	Utp12 domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUA1	A0A0K0DXQ0	Utp12 domain-containing protein.	Brix domain-containing protein.	0.999
A0A0K0DUA1	A0A0K0E0I7	Utp12 domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUA1	A0A0K0E0N1	Utp12 domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUA1	A0A0K0EKY3	Utp12 domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUA1	A0A0K0EQQ2	Utp12 domain-containing protein.	Bms1-type G domain-containing protein.	0.999
A0A0K0DUA1	A0A0K0EQY0	Utp12 domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUA1	A0A0K0ETG9	Utp12 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.997
A0A0K0DUI9	A0A0K0DUA1	BP28CT domain-containing protein.	Utp12 domain-containing protein.	0.999
A0A0K0DUI9	A0A0K0DVH7	BP28CT domain-containing protein.	CBF domain-containing protein.	0.998
A0A0K0DUI9	A0A0K0DW02	BP28CT domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUI9	A0A0K0DXQ0	BP28CT domain-containing protein.	Brix domain-containing protein.	0.997
A0A0K0DUI9	A0A0K0E0I7	BP28CT domain-containing protein.	Uncharacterized protein.	0.998
A0A0K0DUI9	A0A0K0E0N1	BP28CT domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUI9	A0A0K0EKY3	BP28CT domain-containing protein.	Uncharacterized protein.	0.996
A0A0K0DUI9	A0A0K0EQQ2	BP28CT domain-containing protein.	Bms1-type G domain-containing protein.	0.999
A0A0K0DUI9	A0A0K0EQY0	BP28CT domain-containing protein.	Uncharacterized protein.	0.999
A0A0K0DUI9	A0A0K0ETG9	BP28CT domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.998

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.739

expected number of edges:

20

PPI enrichment p-value:

0.0104

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

6 of 12

1.94

3.13

7.92e-08

GO:0006091

Generation of precursor metabolites and energy

7 of 27

1.66

2.62

7.92e-08

GO:0006006

Glucose metabolic process

4 of 8

1.94

2.31

1.28e-05

GO:0006094

Gluconeogenesis

3 of 5

2.02

1.82

0.00024

GO:0016310

Phosphorylation

8 of 109

1.11

1.32

1.07e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000015

Phosphopyruvate hydratase complex

2 of 2

2.25

0.95

0.0177

GO:0009986

Cell surface

2 of 3

2.07

0.93

0.0177

GO:0009274

Peptidoglycan-based cell wall

2 of 5

1.85

0.87

0.0204

GO:0005576

Extracellular region

2 of 13

1.43

0.63

0.0498

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25152889

(2014) Metabolic Engineering of Escherichia coli for Production of Mixed-Acid Fermentation End Products.

5 of 12

1.87

2.43

3.85e-06

PMID:32432104

(2020) Recent Advances in Metabolically Engineered Microorganisms for the Production of Aromatic Chemicals Derived From Aromatic Amino Acids.

3 of 8

1.82

1.22

0.0035

PMID:35638860

(2022) Metatranscriptomics Unravel Composition, Drivers, and Functions of the Active Microorganisms in Light-Flavor Liquor Fermentation.

3 of 11

1.68

1.11

0.0051

PMID:38298832

(2024) Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics.

2 of 2

2.25

1.0

0.0139

PMID:37969339

(2023) Complete genome sequence of Pediococcus acidilactici CACC 537 isolated from canine.

2 of 3

2.07

0.92

0.0185

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2073

Glycolysis, and Aldehyde-lyase activity

8 of 15

1.97

4.48

7.08e-12

CL:2067

Carbon metabolism, and Alcohol dehydrogenase-like, N-terminal

9 of 63

1.4

2.34

6.10e-10

CL:2075

Glycolysis, and Aldehyde-lyase activity

4 of 8

1.94

2.32

1.20e-05

CL:982

Glycerate kinase, and Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

2 of 5

1.85

0.84

0.0245

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

paci00260

Glycine, serine and threonine metabolism

4 of 7

2.0

2.68

1.97e-06

paci00680

Methane metabolism

5 of 15

1.77

2.64

3.74e-07

paci00010

Glycolysis / Gluconeogenesis

7 of 35

1.55

2.57

8.86e-09

paci01200

Carbon metabolism

9 of 59

1.43

2.53

6.95e-11

paci01230

Biosynthesis of amino acids

7 of 37

1.52

2.5

1.00e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

6 of 9

2.07

3.77

4.78e-09

KW-0312

Gluconeogenesis

3 of 4

2.12

1.76

0.00037

KW-0964

Secreted

2 of 3

2.07

0.97

0.0152

KW-0456

Lyase

3 of 25

1.32

0.78

0.0161

KW-0670

Pyruvate

2 of 9

1.59

0.66

0.0491

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01193

Enolase, N-terminal domain

2 of 2

2.25

0.96

0.0166

SM01192

Enolase, C-terminal TIM barrel domain

2 of 2

2.25

0.96

0.0166

SM00855

Phosphoglycerate mutase family

2 of 6

1.77

0.82

0.0256

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