A0A0K0E652 protein (Strongyloides stercoralis)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:

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[Homology]

Score

A0A0K0E652

Uncharacterized protein. (525 aa)

Predicted Functional Partners:

A0A0K0DS90

0.749

A0A0K0E065

0.725

A0A0K0DW27

0.724

A0A0K0DWC8

0.721

A0A0K0ES32

0.712

A0A0K0EEV1

0.623

A0A0K0DWZ6

0.587

A0A0K0ETP4

0.587

A0A0K0DSL0

0.585

A0A0K0E3G7

0.585

Your Current Organism:

Strongyloides stercoralis

NCBI taxonomy Id: 6248
Other names: S. stercoralis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0K0DS90	A0A0K0DSL0	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Myotubularin phosphatase domain-containing protein.	0.869
A0A0K0DS90	A0A0K0DW27	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein.	0.884
A0A0K0DS90	A0A0K0DWC8	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 3-kinase regulatory/accessory subunit.	0.812
A0A0K0DS90	A0A0K0DWZ6	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Myotubularin phosphatase domain-containing protein.	0.885
A0A0K0DS90	A0A0K0E065	Phosphatidylinositol 3-kinase catalytic subunit type 3.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.843
A0A0K0DS90	A0A0K0E3G7	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein.	0.899
A0A0K0DS90	A0A0K0E652	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein.	0.749
A0A0K0DS90	A0A0K0ES32	Phosphatidylinositol 3-kinase catalytic subunit type 3.	SAC domain-containing protein.	0.885
A0A0K0DS90	A0A0K0ETP4	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Myotubularin phosphatase domain-containing protein.	0.815
A0A0K0DSL0	A0A0K0DS90	Myotubularin phosphatase domain-containing protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.869
A0A0K0DSL0	A0A0K0DW27	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.825
A0A0K0DSL0	A0A0K0DWZ6	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.902
A0A0K0DSL0	A0A0K0E065	Myotubularin phosphatase domain-containing protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.805
A0A0K0DSL0	A0A0K0E3G7	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.833
A0A0K0DSL0	A0A0K0E652	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.585
A0A0K0DSL0	A0A0K0ES32	Myotubularin phosphatase domain-containing protein.	SAC domain-containing protein.	0.868
A0A0K0DSL0	A0A0K0ETP4	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.836
A0A0K0DW27	A0A0K0DS90	Uncharacterized protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.884
A0A0K0DW27	A0A0K0DSL0	Uncharacterized protein.	Myotubularin phosphatase domain-containing protein.	0.825
A0A0K0DW27	A0A0K0DWZ6	Uncharacterized protein.	Myotubularin phosphatase domain-containing protein.	0.914

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.776

expected number of edges:

13

PPI enrichment p-value:

0.000137

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006596

Polyamine biosynthetic process

6 of 25

3.01

6.95

1.07e-13

GO:0006591

Ornithine metabolic process

5 of 14

3.18

6.26

3.26e-12

GO:0006525

Arginine metabolic process

5 of 20

3.02

5.9

1.19e-11

GO:1901605

Alpha-amino acid metabolic process

9 of 321

2.07

5.54

1.97e-14

GO:0009446

Putrescine biosynthetic process

4 of 8

3.32

5.14

4.61e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016813

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

5 of 16

3.12

5.87

1.61e-11

GO:0004053

Arginase activity

3 of 3

3.63

3.62

3.05e-07

GO:0008783

Agmatinase activity

2 of 2

3.63

2.01

0.00024

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

2 of 4

3.32

1.89

0.00039

GO:0004586

Ornithine decarboxylase activity

2 of 5

3.23

1.88

0.00041

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:3761021

(1986) Urea cycle activity and arginine formation in rainbow trout (Salmo gairdneri)

3 of 3

3.63

3.43

6.78e-07

PMID:29238889

(2018) Immunomodulatory effects of Rhodomyrtus tomentosa leaf extract and its derivative compound, rhodomyrtone, on head kidney macrophages of rainbow trout (Oncorhynchus mykiss).

3 of 3

3.63

3.43

6.78e-07

PMID:26600157

(2015) Widespread Natural Occurrence of Hydroxyurea in Animals.

3 of 3

3.63

3.43

6.78e-07

PMID:34578212

(2021) Intestinal Transcriptomic and Histologic Profiling Reveals Tissue Repair Mechanisms Underlying Resistance to the Parasite Ceratonova shasta.

3 of 5

3.4

3.42

6.78e-07

PMID:34201988

(2021) Post-Prandial Amino Acid Changes in Gilthead Sea Bream.

3 of 5

3.4

3.42

6.78e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:55228

Arginase, and Agmatinase activity

5 of 5

3.63

6.76

5.91e-13

CL:57371

Polyamine biosynthetic process, and UDP-N-acetylglucosamine biosynthetic process

3 of 34

2.57

2.19

8.74e-05

CL:60604

Mixed, incl. S-methyl-5-thioadenosine phosphorylase activity, and Spermine synthase, animal

2 of 6

3.15

1.57

0.0015

CL:57417

Ornithine decarboxylase, and Ornithine decarboxylase antizyme

2 of 6

3.15

1.57

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

9 of 199

2.28

7.41

6.59e-18

map00270

Cysteine and methionine metabolism

4 of 157

2.03

2.64

2.98e-06

map00220

Arginine biosynthesis

3 of 73

2.24

2.3

3.42e-05

map00480

Glutathione metabolism

3 of 194

1.81

1.59

0.00048

map01230

Biosynthesis of amino acids

3 of 278

1.66

1.35

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-351143

Agmatine biosynthesis

4 of 4

3.63

5.54

1.00e-10

MAP-71291

Metabolism of amino acids and derivatives

11 of 664

1.84

5.28

9.44e-18

MAP-351202

Metabolism of polyamines

6 of 153

2.22

4.43

3.73e-10

MAP-70635

Urea cycle

3 of 11

3.06

3.25

1.21e-06

MAP-1237112

Methionine salvage pathway

2 of 6

3.15

1.88

0.00040

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0835

Urea cycle

3 of 3

3.63

3.98

6.89e-08

KW-0056

Arginine metabolism

3 of 3

3.63

3.98

6.89e-08

KW-0620

Polyamine biosynthesis

2 of 4

3.32

2.25

8.65e-05

KW-0464

Manganese

3 of 75

2.23

2.1

8.65e-05

KW-0378

Hydrolase

4 of 950

1.25

0.94

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00491

Arginase family

4 of 4

3.63

5.2

4.09e-10

PF02784

Pyridoxal-dependent decarboxylase, pyridoxal binding domain

2 of 5

3.23

1.52

0.0018

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020855

Ureohydrolase, manganese-binding site

4 of 4

3.63

4.95

1.19e-09

IPR006035

Ureohydrolase

4 of 4

3.63

4.95

1.19e-09

IPR023696

Ureohydrolase domain superfamily

4 of 30

2.75

3.54

2.61e-07

IPR014033

Arginase

3 of 3

3.63

3.5

4.92e-07

IPR022657

Orn/DAP/Arg decarboxylase 2, conserved site

2 of 3

3.45

1.67

0.0010

(more ...)

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