STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A0K0EEJ7DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (846 aa)    
Predicted Functional Partners:
A0A0K0EEJ6
HATPase_c domain-containing protein.
 
     0.940
A0A0K0DTG5
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.875
A0A0K0DVS0
Small ubiquitin-related modifier.
    
 0.841
A0A0K0DTY4
Structural maintenance of chromosomes protein.
   
 
 0.829
A0A0K0ET11
DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.
  
  
 0.827
A0A0K0EDH0
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.777
A0A0K0ENZ3
Uncharacterized protein.
   
 0.709
A0A0K0DZN2
SP-RING-type domain-containing protein.
    
 0.695
A0A0K0E3K2
Uncharacterized protein.
    
 0.695
A0A0K0E9S2
SP-RING-type domain-containing protein.
    
 0.695
Your Current Organism:
Strongyloides stercoralis
NCBI taxonomy Id: 6248
Other names: S. stercoralis
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