STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (435 aa)    
Predicted Functional Partners:
age-1
Phosphatidylinositol 3-kinase age-1; Belongs to the PI3/PI4-kinase family.
    
 0.997
irs1-b
Insulin receptor substrate 1-B.
    
 0.976
IRS1
Insulin receptor substrate 1.
    
 0.976
akt-1
Protein kinase C.
   
 0.945
Cbl
E3 ubiquitin-protein ligase CBL.
    
 0.943
cblb
E3 ubiquitin-protein ligase CBL-B.
    
 0.943
let-23
Receptor protein-tyrosine kinase.
    
 0.936
ced-2
Cell death abnormality protein 2.
    
 0.920
Myo9a
Unconventional myosin-IXa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
     
 0.914
MYO9B
Unconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
     
 0.914
Your Current Organism:
Toxocara canis
NCBI taxonomy Id: 6265
Other names: T. canis, dog roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.