STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cnnm4-2Metal transporter CNNM4. (973 aa)    
Predicted Functional Partners:
M106.4
Putative GMP synthase [glutamine-hydrolyzing].
  
 
 0.742
Gmps
GMP synthase [glutamine-hydrolyzing].
  
 
 0.742
M106.4-2
Putative GMP synthase [glutamine-hydrolyzing].
  
 
 0.742
ATIC
Bifunctional purine biosynthesis protein PURH.
    
 0.711
ATIC-2
Bifunctional purine biosynthesis protein PURH.
    
 0.711
HPRT1
Hypoxanthine-guanine phosphoribosyltransferase.
  
 
 0.692
T19B4.3
Adenine phosphoribosyltransferase.
  
 
 0.682
Tcan_15839
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.672
Tcan_15837
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
  
 
 0.672
Tcan_04990
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.670
Your Current Organism:
Toxocara canis
NCBI taxonomy Id: 6265
Other names: T. canis, dog roundworm
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