Tcan_08719 protein (Toxocara canis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Tcan_08719

Uncharacterized protein. (196 aa)

Predicted Functional Partners:

Tcan_12675

0.999

SEC61B

0.844

SGTB

0.782

GET4

0.778

Serp2

0.687

TMEM208

0.682

Sec61a2

0.670

emc3

0.650

Emc6

0.646

GART

0.618

Your Current Organism:

Toxocara canis

NCBI taxonomy Id: 6265
Other names: T. canis, dog roundworm

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Emc6	Sec61a2	A0A0B2VL35	A0A0B2USR9	ER membrane protein complex subunit 6.	Protein transport protein Sec61 subunit alpha isoform 2.	0.620
Emc6	TMEM208	A0A0B2VL35	A0A0B2UV04	ER membrane protein complex subunit 6.	Transmembrane protein.	0.450
Emc6	Tcan_08719	A0A0B2VL35	A0A0B2V934	ER membrane protein complex subunit 6.	Uncharacterized protein.	0.646
Emc6	Tcan_12675	A0A0B2VL35	A0A0B2V467	ER membrane protein complex subunit 6.	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	0.633
Emc6	emc3	A0A0B2VL35	A0A0B2VM09	ER membrane protein complex subunit 6.	ER membrane protein complex subunit 3.	0.995
GART	Tcan_08719	A0A0B2V3P5	A0A0B2V934	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Uncharacterized protein.	0.618
GART	Tcan_12675	A0A0B2V3P5	A0A0B2V467	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	0.600
GET4	SEC61B	A0A0B2VZ97	A0A0B2VFE8	Golgi to ER traffic protein 4-like protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.746
GET4	SGTB	A0A0B2VZ97	A0A0B2UTD7	Golgi to ER traffic protein 4-like protein.	Small glutamine-rich tetratricopeptide repeat-containing protein beta.	0.982
GET4	Sec61a2	A0A0B2VZ97	A0A0B2USR9	Golgi to ER traffic protein 4-like protein.	Protein transport protein Sec61 subunit alpha isoform 2.	0.546
GET4	TMEM208	A0A0B2VZ97	A0A0B2UV04	Golgi to ER traffic protein 4-like protein.	Transmembrane protein.	0.594
GET4	Tcan_08719	A0A0B2VZ97	A0A0B2V934	Golgi to ER traffic protein 4-like protein.	Uncharacterized protein.	0.778
GET4	Tcan_12675	A0A0B2VZ97	A0A0B2V467	Golgi to ER traffic protein 4-like protein.	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	0.998
SEC61B	GET4	A0A0B2VFE8	A0A0B2VZ97	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	Golgi to ER traffic protein 4-like protein.	0.746
SEC61B	SGTB	A0A0B2VFE8	A0A0B2UTD7	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	Small glutamine-rich tetratricopeptide repeat-containing protein beta.	0.856
SEC61B	Sec61a2	A0A0B2VFE8	A0A0B2USR9	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	Protein transport protein Sec61 subunit alpha isoform 2.	0.999
SEC61B	Serp2	A0A0B2VFE8	A0A0B2VYY8	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	Stress-associated endoplasmic reticulum protein 2.	0.846
SEC61B	TMEM208	A0A0B2VFE8	A0A0B2UV04	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	Transmembrane protein.	0.517
SEC61B	Tcan_08719	A0A0B2VFE8	A0A0B2V934	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	Uncharacterized protein.	0.844
SEC61B	Tcan_12675	A0A0B2VFE8	A0A0B2V467	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	0.843