STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMGCR3-hydroxy-3-methylglutaryl-coenzyme A reductase. (651 aa)    
Predicted Functional Partners:
F25B4.6
Hydroxymethylglutaryl-CoA synthase.
  
 
 0.993
F25B4.6-2
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  
 
 0.993
MVK
Mevalonate kinase.
  
 0.952
MVD
Diphosphomevalonate decarboxylase.
  
 
 0.943
Prkag2-2
5'-AMP-activated protein kinase subunit gamma-2.
    
 0.876
FAXDC2
Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family.
   
  
 0.874
Hmgcl
Hydroxymethylglutaryl-CoA lyase, mitochondrial.
    
 0.873
AMFR
E3 ubiquitin-protein ligase AMFR.
   
 
 0.859
sel-11
E3 ubiquitin-protein ligase hrd-1; Belongs to the syntaxin family.
   
 
 0.857
aak-2
Non-specific serine/threonine protein kinase.
    
 0.854
Your Current Organism:
Toxocara canis
NCBI taxonomy Id: 6265
Other names: T. canis, dog roundworm
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