STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (459 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
  
 0.808
recX
Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.
  
  
 0.754
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.754
EEP28671.1
Malic enzyme, NAD binding domain protein; KEGG: smu:SMU.137 2.0e-245 mleS; malolactic enzyme K00027.
       0.720
EEP28674.1
ATPase family associated with various cellular activities (AAA); KEGG: sab:SAB0475 2.5e-215 clpC; endopeptidase K03696; Psort location: Cytoplasmic, score: 9.98; Belongs to the ClpA/ClpB family.
  
  
 0.656
EEP28673.1
Hypothetical protein.
       0.628
EEP28498.1
UvrD/REP helicase; KEGG: sth:STH611 1.8e-70 ATP-dependent DNA helicase K01529; Psort location: Cytoplasmic, score: 8.87.
   
  
 0.585
EEP28541.1
Putative ATP-dependent DNA helicase PcrA; KEGG: tte:TTE0604 5.7e-175 uvrD; Superfamily I DNA and RNA helicases K03657; Psort location: Cytoplasmic, score: 8.87.
   
  
 0.585
uvrC
Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
   
  
 0.568
EEP28670.1
Hypothetical protein.
       0.555
Your Current Organism:
Shuttleworthia satelles
NCBI taxonomy Id: 626523
Other names: S. satelles DSM 14600, Shuttleworthia satelles DSM 14600, Shuttleworthia satelles VPI D143K-13, Shuttleworthia satelles str. DSM 14600, Shuttleworthia satelles strain DSM 14600
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