STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
recJKEGG: cac:CAC2232 1.3e-138 recJ; SsDNA exonuclease, RecJ K07462; Psort location: Cytoplasmic, score: 8.87. (590 aa)    
Predicted Functional Partners:
EEP28703.1
KEGG: ctc:CTC02090 5.0e-114 recQ; ATP-dependent DNA helicase recQ K03654; Psort location: Cytoplasmic, score: 8.87.
   
 0.838
priA
Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
 
     0.686
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
   
 0.646
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
    
 
 0.616
secD
Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
 
   
 0.574
mutL
DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
  
   
 0.546
EEP27731.1
comF family protein; KEGG: chu:CHU_3495 6.3e-20 purF; amidophosphoribosyltransferase K00764; Psort location: Cytoplasmic, score: 8.87.
 
     0.530
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
    0.495
murB
UDP-N-acetylmuramate dehydrogenase; Cell wall formation.
 
    0.495
EEP28448.1
DHHA1 domain protein; KEGG: tma:TM0715 4.9e-12 tRNA nucleotidyltransferase (CCA-adding enzyme) K00974; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.491
Your Current Organism:
Shuttleworthia satelles
NCBI taxonomy Id: 626523
Other names: S. satelles DSM 14600, Shuttleworthia satelles DSM 14600, Shuttleworthia satelles VPI D143K-13, Shuttleworthia satelles str. DSM 14600, Shuttleworthia satelles strain DSM 14600
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.