node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hpt | KXK64825.1 | HMPREF3293_01832 | HMPREF3293_02066 | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.915 |
Hpt | KXK65548.1 | HMPREF3293_01832 | HMPREF3293_01762 | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | 0.428 |
Hpt | apt | HMPREF3293_01832 | HMPREF3293_02252 | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.928 |
Hpt | gmk | HMPREF3293_01832 | HMPREF3293_02211 | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.919 |
Hpt | guaA | HMPREF3293_01832 | HMPREF3293_02115 | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.968 |
Hpt | guaB | HMPREF3293_01832 | HMPREF3293_02113 | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.923 |
Hpt | surE | HMPREF3293_01832 | HMPREF3293_02357 | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.901 |
KXK64825.1 | Hpt | HMPREF3293_02066 | HMPREF3293_01832 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.915 |
KXK64825.1 | guaA | HMPREF3293_02066 | HMPREF3293_02115 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.971 |
KXK64825.1 | guaB | HMPREF3293_02066 | HMPREF3293_02113 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.931 |
KXK64825.1 | surE | HMPREF3293_02066 | HMPREF3293_02357 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.906 |
KXK65548.1 | Hpt | HMPREF3293_01762 | HMPREF3293_01832 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | KEGG: cbl:CLK_2990 2.1e-55 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.428 |
KXK65548.1 | LysS | HMPREF3293_01762 | HMPREF3293_01164 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | lysine--tRNA ligase; KEGG: ccl:Clocl_3911 8.9e-176 lysyl-tRNA synthetase (class II); K04567 lysyl-tRNA synthetase, class II; Psort location: Cytoplasmic, score: 10.00. | 0.932 |
KXK65548.1 | apt | HMPREF3293_01762 | HMPREF3293_02252 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.760 |
KXK65548.1 | argS | HMPREF3293_01762 | HMPREF3293_01508 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | arginine--tRNA ligase; KEGG: cst:CLOST_1149 1.2e-166 argS; arginyl-tRNA synthetase 2 K01887; Psort location: Cytoplasmic, score: 9.97. | 0.616 |
KXK65548.1 | gmk | HMPREF3293_01762 | HMPREF3293_02211 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.674 |
KXK65548.1 | guaA | HMPREF3293_01762 | HMPREF3293_02115 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.976 |
KXK65548.1 | guaB | HMPREF3293_01762 | HMPREF3293_02113 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.836 |
KXK65548.1 | pyrG | HMPREF3293_01762 | HMPREF3293_01026 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.598 |
KXK65548.1 | surE | HMPREF3293_01762 | HMPREF3293_02357 | KEGG: tjr:TherJR_0822 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.26. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.450 |