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query proteins and first shell of interactors
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second shell of interactors
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folCProtein synonym:folylpoly-gamma-glutamate synthetase; protein synonym:tetrahydrofolate synthase; protein synonym:tetrahydrofolylpolyglutamate synthase. (447 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Protein synonym:DHPS; protein synonym:dihydropteroate pyrophosphorylase.
 
 0.997
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.937
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.874
accD
acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
  
  
 0.768
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Protein synonym:6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; protein synonym:7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.
 
  
 0.716
ligH
10-formyltetrahydrofolate synthetase.
 
 
 0.710
rlpA-2
Conserved hypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
  
  
 0.710
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.687
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.686
folE
GTP cyclohydrolase I.
  
  
 0.678
Your Current Organism:
Sphingobium sp. SYK6
NCBI taxonomy Id: 627192
Other names: S. sp. SYK-6, Sphingobium sp. SYK-6
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