bma-epac-1 protein (Brugia malayi) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

bma-epac-1

BMA-EPAC-1. (1079 aa)

Predicted Functional Partners:

Bm1_39445

0.967

Bm1_24180

0.894

Bm1_31910

0.763

bma-lin-45

0.671

bma-sipa-1

0.652

Bma-irk-2

0.606

A0A5S6PPB2

0.606

bma-ras-2

0.589

Bma-ssr-2

0.589

bma-let-60

0.589

Your Current Organism:

Brugia malayi

NCBI taxonomy Id: 6279
Other names: B. malayi, agent of lymphatic filariasis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5S6PPB2	bma-epac-1	A0A5S6PPB2	A0A0I9N586	BMA-IRK-2, isoform f.	BMA-EPAC-1.	0.606
Bm1_24180	Bm1_31910	A0A5S6PEH0	A0A5S6PML4	Uncharacterized protein.	Bm4285.	0.813
Bm1_24180	bma-epac-1	A0A5S6PEH0	A0A0I9N586	Uncharacterized protein.	BMA-EPAC-1.	0.894
Bm1_24180	bma-let-60	A0A5S6PEH0	A0A0K0J2J0	Uncharacterized protein.	BMA-LET-60.	0.642
Bm1_24180	bma-lin-45	A0A5S6PEH0	A0A0K0JQW7	Uncharacterized protein.	BMA-LIN-45, isoform a; BMA-LIN-45, isoform b.	0.840
Bm1_24180	bma-sipa-1	A0A5S6PEH0	A0A0K0JLH8	Uncharacterized protein.	BMA-SIPA-1.	0.765
Bm1_31910	Bm1_24180	A0A5S6PML4	A0A5S6PEH0	Bm4285.	Uncharacterized protein.	0.813
Bm1_31910	Bm1_39445	A0A5S6PML4	A0A0K0J5Y2	Bm4285.	BMA-RAP-1.	0.927
Bm1_31910	Bma-ssr-2	A0A5S6PML4	A0A0H5SB49	Bm4285.	BMA-SSR-2.	0.580
Bm1_31910	bma-epac-1	A0A5S6PML4	A0A0I9N586	Bm4285.	BMA-EPAC-1.	0.763
Bm1_31910	bma-let-60	A0A5S6PML4	A0A0K0J2J0	Bm4285.	BMA-LET-60.	0.604
Bm1_31910	bma-ras-2	A0A5S6PML4	A0A0H5S0W7	Bm4285.	BMA-RAS-2.	0.582
Bm1_39445	Bm1_31910	A0A0K0J5Y2	A0A5S6PML4	BMA-RAP-1.	Bm4285.	0.927
Bm1_39445	bma-epac-1	A0A0K0J5Y2	A0A0I9N586	BMA-RAP-1.	BMA-EPAC-1.	0.967
Bm1_39445	bma-let-60	A0A0K0J5Y2	A0A0K0J2J0	BMA-RAP-1.	BMA-LET-60.	0.724
Bm1_39445	bma-lin-45	A0A0K0J5Y2	A0A0K0JQW7	BMA-RAP-1.	BMA-LIN-45, isoform a; BMA-LIN-45, isoform b.	0.996
Bm1_39445	bma-sipa-1	A0A0K0J5Y2	A0A0K0JLH8	BMA-RAP-1.	BMA-SIPA-1.	0.797
Bma-irk-2	bma-epac-1	A0A1I9G870	A0A0I9N586	BMA-IRK-2, isoform f.	BMA-EPAC-1.	0.606
Bma-ssr-2	Bm1_31910	A0A0H5SB49	A0A5S6PML4	BMA-SSR-2.	Bm4285.	0.580
Bma-ssr-2	bma-epac-1	A0A0H5SB49	A0A0I9N586	BMA-SSR-2.	BMA-EPAC-1.	0.589

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.929

expected number of edges:

25

PPI enrichment p-value:

5.97e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019646

Aerobic electron transport chain

10 of 44

2.5

9.29

7.54e-21

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

10 of 47

2.47

9.19

7.54e-21

GO:0006122

Mitochondrial electron transport, ubiquinol to cytochrome c

6 of 12

2.84

6.64

2.44e-13

GO:0006123

Mitochondrial electron transport, cytochrome c to oxygen

4 of 10

2.75

3.84

6.75e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009055

Electron transfer activity

5 of 47

2.17

3.17

3.26e-07

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

4 of 35

2.2

2.51

1.13e-05

GO:0015078

Proton transmembrane transporter activity

3 of 54

1.89

1.27

0.0031

GO:0008121

Ubiquinol-cytochrome-c reductase activity

2 of 7

2.6

1.27

0.0047

GO:0016491

Oxidoreductase activity

6 of 577

1.16

1.05

0.00056

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070069

Cytochrome complex

10 of 26

2.73

11.22

1.18e-23

GO:0098803

Respiratory chain complex

11 of 61

2.4

9.85

1.18e-23

GO:0005746

Mitochondrial respirasome

11 of 61

2.4

9.85

1.18e-23

GO:0098800

Inner mitochondrial membrane protein complex

11 of 101

2.18

8.16

4.09e-22

GO:0005750

Mitochondrial respiratory chain complex III

6 of 12

2.84

7.06

3.62e-14

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:39354118

(2024) Novel fungicide and neonicotinoid insecticide impair flight behavior in pollen foraging honey bees, Apis mellifera.

3 of 7

2.78

1.97

0.00025

PMID:31182611

(2019) Loss of the HIF pathway in a widely distributed intertidal crustacean, the copepod Tigriopus californicus.

2 of 6

2.67

0.72

0.0491

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7906

Cytochrome complex

10 of 18

2.89

12.04

1.77e-24

CL:7841

Respiratory chain complex

11 of 55

2.44

10.21

4.72e-24

CL:7907

Respiratory chain complex III

7 of 11

2.95

8.53

6.41e-17

CL:7919

Respiratory chain complex III

4 of 5

3.05

4.58

3.96e-09

CL:7909

Respiratory chain complex III

3 of 5

2.92

3.01

3.09e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ame00190

Oxidative phosphorylation

11 of 86

2.25

8.83

4.86e-23

ame01100

Metabolic pathways

11 of 820

1.27

2.16

7.47e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

11 of 93

2.22

8.25

1.12e-21

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

11 of 111

2.14

7.68

3.52e-21

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

11 of 179

1.93

6.03

3.63e-19

MAP-9707564

Cytoprotection by HMOX1

4 of 52

2.03

2.36

1.42e-05

MAP-5628897

TP53 Regulates Metabolic Genes

4 of 72

1.89

2.06

4.11e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

8 of 23

2.69

8.34

2.41e-17

GOCC:0070469

Respirasome

9 of 65

2.29

7.19

3.29e-17

GOCC:0005746

Mitochondrial respirasome

8 of 45

2.39

7.0

8.98e-16

GOCC:0098803

Respiratory chain complex

8 of 47

2.37

6.95

9.25e-16

GOCC:0005750

Mitochondrial respiratory chain complex III

5 of 10

2.84

5.66

2.29e-11

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 9

2.49

1.16

0.0074

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