STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bma-lonp-1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (966 aa)    
Predicted Functional Partners:
Bm1_03955
GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.
  
  
 0.955
Bm1_57610
Bm4855.
 
 
 0.906
bma-clpp-1
ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family.
  
 
 0.894
bma-hsp-90
BMA-DAF-21.
  
  
 0.846
Bm1_20215
Bm5434.
  
  
 0.846
A0A5S6PAT7
Uncharacterized protein.
  
  
 0.833
bma-hsp-60
Bm6327; Belongs to the chaperonin (HSP60) family.
  
 0.804
bma-vars-1
BMA-VARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.749
A0A5S6PSD7
Bm6438.
  
 
 0.736
A0A5S6PSG4
Bm6438.
  
 
 0.736
Your Current Organism:
Brugia malayi
NCBI taxonomy Id: 6279
Other names: B. malayi, agent of lymphatic filariasis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.