STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BPAG_LOCUS1301Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1360 aa)    
Predicted Functional Partners:
A0A0N4TTZ1
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.957
A0A0N4TYA0
Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
     
 0.923
BPAG_LOCUS161
Uncharacterized protein.
    
 0.870
BPAG_LOCUS9720
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.870
A0A0N4TTQ1
Protein-serine/threonine kinase.
     
 0.857
A0A158PRQ2
Uncharacterized protein.
      
 0.760
BPAG_LOCUS9434
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
   0.678
BPAG_LOCUS9028
Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.
    
   0.634
A0A0N4TQ51
PUA domain-containing protein.
    
 
 0.620
A0A0N4TXG2
CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
      
 0.601
Your Current Organism:
Brugia pahangi
NCBI taxonomy Id: 6280
Other names: B. pahangi
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.