Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
A0A044QL80Uncharacterized protein. (1029 aa)    
Predicted Functional Partners:
A0A2K6WJ54
Uncharacterized protein.
   
 0.993
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.989
A0A044UU69
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
 0.987
A0A044UWY4
Uncharacterized protein.
   
 0.987
A0A044TNP7
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
 0.986
A0A044VFY4
Uncharacterized protein.
   
 0.986
A0A044UV21
WD_REPEATS_REGION domain-containing protein; Belongs to the MRE11/RAD32 family.
   
 0.985
A0A044UE18
Mcl1_mid domain-containing protein.
   
 
 0.981
A0A044V544
Uncharacterized protein.
   
 0.979
A0A044S4A8
Uncharacterized protein.
   
 
 0.973
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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