Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
A0A044RGD2Uncharacterized protein. (172 aa)    
Predicted Functional Partners:
A0A2K6WF75
Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.
    
   0.885
A0A044RBZ6
tRNA-binding domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
    
   0.877
A0A044TZU3
2-Hacid_dh_C domain-containing protein.
    
   0.803
A0A044UAU0
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
   0.781
A0A044SHJ6
CBFD_NFYB_HMF domain-containing protein.
    
 
 0.747
A0A044SSL2
Uncharacterized protein.
      
 0.678
A0A044SIT6
Uncharacterized protein.
    
   0.623
A0A044T956
Uncharacterized protein.
    
   0.623
A0A044R7U0
Uncharacterized protein.
    
   0.614
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
    
   0.614
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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