STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A044RH56Helicase C-terminal domain-containing protein. (160 aa)    
Predicted Functional Partners:
A0A044RJX1
Uncharacterized protein.
   
 0.818
A0A2K6WJ54
Uncharacterized protein.
  
 
 0.783
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 
 0.761
A0A044UV21
WD_REPEATS_REGION domain-containing protein; Belongs to the MRE11/RAD32 family.
  
 0.747
A0A044V3K5
FANCI_HD2 domain-containing protein.
   
 0.703
A0A044UEJ5
AAA_23 domain-containing protein.
  
 
 0.687
A0A044UKX1
Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.
   
 
 0.686
A0A044SXP7
SAE2 domain-containing protein.
    
 0.678
A0A044SAY7
Uncharacterized protein.
  
 
 0.668
A0A044V9Q0
Uncharacterized protein.
  
 
 0.668
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.