Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
A0A044RUI6Uncharacterized protein. (95 aa)    
Predicted Functional Partners:
A0A2K6W190
Uncharacterized protein.
   
 0.599
A0A044VFY4
Uncharacterized protein.
    
 0.585
A0A044RA28
CRC domain-containing protein.
    
 0.578
A0A044UAK1
Uncharacterized protein.
    
 0.578
A0A044U577
WD_REPEATS_REGION domain-containing protein.
    
 0.564
A0A044SF19
Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.540
A0A044T137
Med12 domain-containing protein.
   
 0.540
A0A2K6WIT9
DIRP domain-containing protein.
    
 0.538
A0A044S5B7
Uncharacterized protein.
    
 0.536
A0A044UDM5
Uncharacterized protein.
    
  0.532
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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