Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
A0A044SWL826S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (938 aa)    
Predicted Functional Partners:
A0A044S174
VWFA domain-containing protein.
   
 0.999
A0A044SPM4
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
   
 0.999
A0A044TU88
MPN domain-containing protein.
   
 0.999
A0A044UBE2
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.999
A0A044UX82
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.999
A0A044V4H4
PCI domain-containing protein.
   
 0.999
A0A044V7E0
PCI domain-containing protein.
   
 0.999
A0A044VBS0
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.999
A0A044VH71
PCI domain-containing protein.
   
 0.999
A0A044QPU0
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.998
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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