Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
A0A044SWP5MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (422 aa)    
Predicted Functional Partners:
A0A044QN85
Adaptin_N domain-containing protein.
   
 0.998
A0A044RD38
Clat_adaptor_s domain-containing protein.
   
 0.998
A0A044QS31
AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.
   
 0.997
A0A2K6WHM3
AP-1 complex subunit gamma.
   
 0.928
A0A044TTX4
AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
   
 0.904
A0A044V3Q6
Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
   
 0.819
A0A2K6VPP9
Uncharacterized protein.
    
 
 0.793
A0A044SNR4
Uncharacterized protein.
    
 
 0.785
A0A044SND5
Uncharacterized protein.
    
 
 0.769
A0A044TLE2
Uncharacterized protein.
    
 
 0.764
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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