STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A044SWP5MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (422 aa)    
Predicted Functional Partners:
A0A044QN85
Adaptin_N domain-containing protein.
   
 0.999
A0A044QS31
AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.
   
 0.999
A0A044RD38
Clat_adaptor_s domain-containing protein.
   
 0.996
A0A2K6WHM3
AP-1 complex subunit gamma.
   
 0.973
A0A044TTX4
AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
   
 0.964
A0A044V3Q6
Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
   
 0.947
A0A044TII1
MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.
     
0.742
A0A044TLE2
Uncharacterized protein.
      
 0.724
A0A044UV10
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
   
 
 0.617
A0A044RJ19
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
     
 0.614
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.