Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
A0A044TY84AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)    
Predicted Functional Partners:
A0A044TII1
MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.
   
 0.999
A0A044TTX4
AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
   
 0.998
A0A044UTM4
AP complex subunit beta.
   
 0.998
A0A044U505
Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.
   
 0.994
A0A044UV10
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
    
 0.994
A0A044U4B9
Uncharacterized protein.
    
 0.991
A0A044QNV1
Uncharacterized protein.
    
 0.984
A0A044QWL9
Uncharacterized protein.
    
 0.978
A0A044U3C1
Uncharacterized protein.
    
  0.973
A0A044QPS1
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
  0.963
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
Server load: low (16%) [HD]