Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
A0A044TYD3Uncharacterized protein; Belongs to the actin-binding proteins ADF family. (593 aa)    
Predicted Functional Partners:
A0A044SSF2
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 0.957
A0A044TR25
WD_REPEATS_REGION domain-containing protein.
   
 
 0.937
A0A044VID9
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 
 0.927
A0A044TKC8
F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 
 0.897
A0A044T5R5
Uncharacterized protein.
    
 
 0.852
A0A044RDC0
Coronin; Belongs to the WD repeat coronin family.
   
 0.833
A0A044V419
Coronin; Belongs to the WD repeat coronin family.
   
 0.833
A0A2K6W7S1
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 0.788
A0A044UE17
Uncharacterized protein.
   
  
 0.766
A0A044S924
Uncharacterized protein; Belongs to the actin family.
   
 0.754
Your Current Organism:
Onchocerca volvulus
NCBI taxonomy Id: 6282
Other names: O. volvulus
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