node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FtsK | dnaA | azo1365 | azo0001 | Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity. | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.704 |
FtsK | dnaB | azo1365 | azo0722 | Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity. | DnaB protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.452 |
FtsK | dnaN | azo1365 | azo0002 | Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity. | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | 0.422 |
FtsK | parA1 | azo1365 | azo0143 | Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity. | ParA family protein; Putative chromosome partitioning protein; High confidence in function and specificity. | 0.672 |
FtsK | parB | azo1365 | azo0146 | Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity. | Probable chromosome partitioning protein,; High confidence in function and specificity; Belongs to the ParB family. | 0.829 |
FtsK | recR | azo1365 | azo0959 | Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.481 |
azo3138 | dnaA | azo3138 | azo0001 | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.886 |
azo3138 | dnaB | azo3138 | azo0722 | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | DnaB protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.847 |
azo3138 | dnaN | azo3138 | azo0002 | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | 0.987 |
azo3138 | gmhA | azo3138 | azo0870 | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | Putative phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. | 0.686 |
azo3138 | hupB | azo3138 | azo0315 | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | DNA-binding protein HU (DNA-binding protein II); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 0.413 |
azo3138 | parA1 | azo3138 | azo0143 | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | ParA family protein; Putative chromosome partitioning protein; High confidence in function and specificity. | 0.592 |
azo3138 | parB | azo3138 | azo0146 | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | Probable chromosome partitioning protein,; High confidence in function and specificity; Belongs to the ParB family. | 0.418 |
dnaA | FtsK | azo0001 | azo1365 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity. | 0.704 |
dnaA | azo3138 | azo0001 | azo3138 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. | 0.886 |
dnaA | dnaB | azo0001 | azo0722 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DnaB protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.954 |
dnaA | dnaN | azo0001 | azo0002 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | 0.994 |
dnaA | gmhA | azo0001 | azo0870 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Putative phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. | 0.855 |
dnaA | gyrB | azo0001 | azo0003 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA topoisomerase (ATP-hydrolysing); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...] | 0.681 |
dnaA | hupB | azo0001 | azo0315 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA-binding protein HU (DNA-binding protein II); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 0.801 |