STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rstBProbable two component sensor histidine kinase,; Specificity unclear. (437 aa)    
Predicted Functional Partners:
rstA
Two component response regulator,; Specificity unclear.
 
 0.971
azo2457
Putative sensory box histidine kinase,; Function unclear.
   
 0.927
azo1817
Conserved hypothetical two-component hybrid sensor and regulator. Homology to ebA6890 of Azoarcus sp. EbN1 of 56% (gnl|keqq|eba:ebA6890(KEGG)). InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR009082 His_kin_homodim. IPR001610 PAC. IPR000700 PAS-assoc_C. IPR000014 PAS_domain. IPR001789 Response_reg. Pfam: PF02518 HATPase_c. PF00512 HisKA. PF00785 PAC. PF00989 PAS. PF00072 Response_reg. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00086 PAC. SM00091 PAS. SM00448 REC. TIGRFAM: TIGR00229 sensory_box; 3 TMHMM reporting 7 transmembra [...]
 
0.912
barA
Putative sensor-regulator protein,; Specificity unclear.
  
 0.889
azo2482
Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...]
  
 0.889
gacS
Putative two-component hybrid sensor and regulator,; Family membership.
  
 0.889
azo3685
Putative hybrid sensor and regulator protein, MmoS) InterPro: IPR003594; ATPbind_ATPase. IPR005467; His_kinase. IPR003661; His_kinA_N. IPR008207; Hpt. IPR001610; PAC. IPR000700; PAS-assoc_C. IPR000014; PAS_domain. IPR001789; Response_reg. Pfam: PF02518; HATPase_c. PF00512; HisKA. PF00785; PAC. PF00989; PAS. PF00072; Response_reg. SMART: SM00387; HATPase_c. SM00388; HisKA. SM00073; HPT. SM00086; PAC. SM00091; PAS. SM00448; REC. TIGRFAM: TIGR00229; sensory_box. TMHMM reporting 2 transmembrane helices; Family membership.
   
 0.880
ompR2
Probable DNA-binding response regulator, ITS CARBOXYL-TERMINAL MOIETY MEDIATES THE MULTIMERIZATION OF THE OMPR PROTEIN. AS A MULTIMER IT TURNS ON THE EXPRESSION OF THE OMPC GENE; AS A MONOMER IT TURNS ON THE EXPRESSION OF THE OMPF GENE; High confidence in function and specificity.
 
 0.878
ompR3
DNA-binding response regulator; Transcriptional regulatory protein, Trans_reg_C. IPR001789 Response_reg. Pfam: PF00486; trans_reg_C. PF00072 response_reg. SMART: SM00448 REC; Specificity unclear.
 
 0.878
ompR1
Transcriptional regulatory protein ompR,Trans_reg_C. IPR001789 Response_reg. Pfam: PF00486; trans_reg_C. PF00072 response_reg. SMART: SM00448 REC. THE N-TERMINUS OF THIS PROTEIN IS REQUIRED FOR THE TRANSCRIPTIONAL EXPRESSION OF BOTH MAJOR OUTER MEMBRANE PROTEIN GENES OMPF AND OMPC; ITS CARBOXYL-TERMINAL MOIETY MEDIATES THE MULTIMERIZATION OF THE OMPR PROTEIN. AS A MULTIMER IT TURNS ON THE EXPRESSION OF THE OMPC GENE; AS A MONOMER IT TURNS ON THE EXPRESSION OF THE OMPF GENE; High confidence in function and specificity.
  
 0.864
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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