STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo0066Probable enoyl-CoA hydratase/isomerase; Enoyl-CoA hydratase and 3-2trans-enoyl-CoA isomerase are two enzymes involved in fatty acid metabolism. ECH catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA and ECI shifts the 3- double bond of the intermediates of unsaturated fatty acid oxidation to the 2-trans position.In Escherichia coli (gene fadB) and Pseudomonas fragi (gene faoA), ECH and ECI are also part of a multifunctional enzyme which contains both a HCDH and a 3-hydroxybutyryl-CoA epimerase domain. InterPro: Enoyl-CoA hydratase/isomerase Entry name TREMBL:Q8PMW0 P [...] (372 aa)    
Predicted Functional Partners:
azo3685
Putative hybrid sensor and regulator protein, MmoS) InterPro: IPR003594; ATPbind_ATPase. IPR005467; His_kinase. IPR003661; His_kinA_N. IPR008207; Hpt. IPR001610; PAC. IPR000700; PAS-assoc_C. IPR000014; PAS_domain. IPR001789; Response_reg. Pfam: PF02518; HATPase_c. PF00512; HisKA. PF00785; PAC. PF00989; PAS. PF00072; Response_reg. SMART: SM00387; HATPase_c. SM00388; HisKA. SM00073; HPT. SM00086; PAC. SM00091; PAS. SM00448; REC. TIGRFAM: TIGR00229; sensory_box. TMHMM reporting 2 transmembrane helices; Family membership.
    
 0.932
azo1817
Conserved hypothetical two-component hybrid sensor and regulator. Homology to ebA6890 of Azoarcus sp. EbN1 of 56% (gnl|keqq|eba:ebA6890(KEGG)). InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR009082 His_kin_homodim. IPR001610 PAC. IPR000700 PAS-assoc_C. IPR000014 PAS_domain. IPR001789 Response_reg. Pfam: PF02518 HATPase_c. PF00512 HisKA. PF00785 PAC. PF00989 PAS. PF00072 Response_reg. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00086 PAC. SM00091 PAS. SM00448 REC. TIGRFAM: TIGR00229 sensory_box; 3 TMHMM reporting 7 transmembra [...]
    
 0.931
azo0694
Putative hybrid sensor and regulator protein,; Specificity unclear.
    
 0.906
azo2362
Putative sensor kinase/response regulator hybrid protein,; Specificity unclear.
    
 0.906
azo2450
Putative two-component system sensor protein,; Function unclear.
    
 0.906
azo0655
Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]
    
  0.859
azo0065
Conserved hypothetical protein; 64% similarity with ABC-type multidrug transport system, ATPase and permease components [Dechloromonas aromatica RCB]. and.
       0.773
paaJ1
THIOLYTIC CLEAVAGE OF BETA-KETOADIPYL-COA TO SUCCINATE AND ACETYL-COA. Entry name:- TREMBL:Q84HH5 InterPro:- IPR002155; Thiolase. Pfam:- PF02803; Thiolase_C; 1. PF00108; Thiolase_N; 1. Identities = 298/398 (74%) Number of predicted TMHs: 0; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.
   
 0.754
fadAx
Probable acyl-CoA thiolase. Homology to fadAx of P. putida of 67% (gnl|keqq|ppu:PP2215(KEGG)). IPR002155; Thiolase. Pfam PF02803; Thiolase_C; 1. PF00108; Thiolase_N; 1. Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC:2.3.1.9) and 3-ketoacyl-CoA thiolase (EC:2.3.1.16). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid -oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of a [...]
   
 0.754
fadA1
Probable 3-ketoacyl-CoA thiolase; Subunit of fatty acid oxidation complex, 3-keto-acyl-coa-thiolase. Activity:-acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA Entry name TREMBL:Q8G967 Prim. accession # Q8G967 Identities = 284/425 (66%) InterPro IPR002155; Thiolase. Pfam PF02803; Thiolase_C; 1. PF00108; Thiolase_N; 1. Number of predicted TMHs: 0 Prediction: Non-secretory protein Signal peptide probability: 0.000; Family membership; Belongs to the thiolase-like superfamily. Thiolase family.
   
 0.754
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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