STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dmpIProbable tautomerase lin2709 (EC 5.3.2.2). TREMBL:Q7UE84: 67% identity, 86% similarity InterPro:IPR004370; Taut. ProDom: PD404143 InterPro: 4-oxalocrotonate tautomerase taut: 4-oxalocrotonate tautomerase No signal peptide no TMH's; High confidence in function and specificity. (67 aa)    
Predicted Functional Partners:
lapH
Conversion of 4-oxalocrotonate into 2-oxopent-4-enoate, involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. Belongs to the todJ/xylI/xylJ/hpcG family, TREMBL:Q8RQD3 (56% identity); SWISSPROT:P23107. Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
    
 0.613
nahK
4-Oxalocrotonate decarboxylase; Similar to TREMBL:Q93JW1 (67% identity); TREMBL:Q9RHN0 (67% identity); SWISSPROT:P49155 (59% identity). Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
    
 0.613
nahI
2-hydroxymuconic semialdehyde dehydrogenase (HMSD). Homology to nahI of P. stutzeri of 73% (TREMBL:Q9S602) 2-HYDROXYMUCONIC ACID SEMIALDEHYDE CAN BE CONVERTED TO 2-HYDROXYPENT-24-DIENOATE EITHER DIRECTLY BY THE ACTION OF 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE (HMSH) OR BY THE ACTION OF THREE SEQUENTIAL ENZYMES THE FIRST OF WHICH IS HMSD. InterPro: Aldehyde dehydrogenase family (IPR002086) Pfam: Aldehyde dehydrogenase family no signal peptide no TMHs proA: gamma-glutamyl phosphate reductas.
     
  0.591
xylE
Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir|JE0112 (52%), to trembl|Q45459 (48%)and to sprot|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.
    
 0.538
nahJ
4-oxalocrotonate tautomerase (EC 5.3.2.-) (4-OT). Catalyzes the ketonization of 2-hydroxymuconate stereoselectively to yield 2-oxo-3-hexenedioate. SPROT:Q9RHM8: 80% identity; 88% similarity InterPro: 4-oxalocrotonate tautomerase InterPro:IPR004370; Taut. ProDom: PD404143; Taut Pfam; PF01361; Tautomerase; 1. taut: 4-oxalocrotonate tautomerase helixturnhelix: reporting nucleic acid binding motif No transmembrane helices; High confidence in function and specificity.
  
  
  0.527
nahY
Putative aromatic hydrocarbon chemotaxis transducer; The ability of bacteria to recognize and swim toward aromatic hydrocarbons is possibly an important prelude to their degradation. In Pseudomonas putida G7,NahY is the receptor required for the chemotaxis to naphthalene. Similar to trembl|Q7NU44 (38%) and to trembl|Q7NY58 (33%). Smart: HAMP domain Pfam (PF00015): Methyl-accepting chemotaxis protein (MCP) signalling domain SignalP reporting Signal Peptide; Specificity unclear.
       0.498
azo0132
Transcriptional regulator, LysR family,; Specificity unclear; Belongs to the LysR transcriptional regulatory family.
       0.455
lapB1
Catechol 2,3-dioxygenase; In Pseudomonas sp. strain KL28 the genes,designated as lap (for long-chain alkylphenols), encoding enzymes for the catabolic 3- and 4-alkylphenol degradation pathway. The lap genes are located in a 13.2 kb region with 14 ORFs in the order lapRBKLMNOPCEHIFG and with the same transcriptional orientation. Catechol 2,3-dioxygenase LapB,; High confidence in function and specificity.
    
 0.432
lapB2
Catechol 2,3-dioxygenase (metapyrocatechase); In Pseudomonas sp. strain KL28 the genes,designated as lap (for long-chain alkylphenols), encoding enzymes for the catabolic 3- and 4-alkylphenol degradation pathway. Catechol 2,3-dioxygenase LapB,; High confidence in function and specificity.
    
 0.432
ilvE1
Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
  0.410
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.