Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pbpAPenicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (629 aa)    
Predicted Functional Partners:
rodA
Rod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 0.999
mreC
Rod shape-determining protein; Involved in formation and maintenance of cell shape.
 
 
 0.987
FtsW
Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.
 0.984
mtgA
Probable monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family.
 
 
 0.980
rlpA
Lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
   
 0.978
dacC
Probable D-alanyl-D-alanine carboxypeptidase. Homology to dacD of E. coli of 41% (sprot|DACD_ECOLI) Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Pfam: D-alanyl-D-alanine carboxypeptidase signal peptide no TMHs; High confidence in function and specificity; Belongs to the peptidase S11 family.
 
 
 0.964
mrcA
Probable penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin- insensitive transglycosylase (EC 2.4.2.-) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.-.-) (DD-transpeptidase)]. Homology to mrcA of N. meningitides of 47% (sprot|PBPA_NEIMA(SRS)) Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By sim [...]
  
 
0.957
mreB
Rod shape-determining protein mreB. INVOLVED IN FORMATION OF THE ROD SHAPE OF THE CELL. MAY ACT AS A NEGATIVE REGULATOR OF FTSI. InterPro: Cell shape determining protein MreB/Mrl mreB: cell shape determining protein; High confidence in function and specificity.
 
 
 
 0.956
FtsL
Putative cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
  
 0.956
FtsQ
Putative cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
  
 0.956
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.