| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| alkB | apbA1 | azo2293 | azo0192 | DNA-directed DNA polymerase; Alkylated DNA repair protein.Probably involved in the repair of alkylated DNA. Provides extensive resistance to alkylating agents.; High confidence in function and specificity. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.535 |
| alkB | apbA2 | azo2293 | azo1994 | DNA-directed DNA polymerase; Alkylated DNA repair protein.Probably involved in the repair of alkylated DNA. Provides extensive resistance to alkylating agents.; High confidence in function and specificity. | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | 0.535 |
| apbA1 | alkB | azo0192 | azo2293 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | DNA-directed DNA polymerase; Alkylated DNA repair protein.Probably involved in the repair of alkylated DNA. Provides extensive resistance to alkylating agents.; High confidence in function and specificity. | 0.535 |
| apbA1 | apbA2 | azo0192 | azo1994 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | 0.727 |
| apbA1 | azo0190 | azo0192 | azo0190 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Conserved hypothetical protein. Homology to an orf of R. oxalatica of 31% (trembl|Q84ES1). Pfam: 37-kD nucleoid-associaed bacterial protein The Escherichia coli nucleoid contains DNA in a condensed but functional form. Analysis of proteins released from isolated spermidine nucleoids after treatment with DNase I reveals significant amounts of two proteins not previously detected in wild-type Escherichia coli. Partial amino-terminal sequencing has identified them as the products of rdgC and yejK. no signal peptide no TMHs. | 0.561 |
| apbA1 | azo0191 | azo0192 | azo0191 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Conserved hypothetical protein; Entry name TREMBL:Q988L8 Prim. accession # Q988L8 InterPro IPR002539; MaoC_dehydratas. Identities = 63/131 (48%) Pfam PF01575; MaoC_dehydratas; 1. Number of predicted TMHs: 0 Probable MaoC protein (Phenylacetic acid degradation protein paaZ). | 0.773 |
| apbA1 | azo1246 | azo0192 | azo1246 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Conserved hypothetical mandelate racemase. Homology to bll6730 of B. japonicum of 76% (trembl|Q89FH0) Mandelate racemase and muconate lactonizing enzyme are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures. InterPro: Mandelate racemase/muconate lactonizing enzyme family (IPR001354) Pfam: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain; Specific [...] | 0.411 |
| apbA1 | azo2783 | azo0192 | azo2783 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | DNA repair system specific for alkylated DNA; Probable RNA-directed RNA polymerase (EC 2.7.7.48) (RNA replicase) (216.5 kDa protein) (ORF1). alkb: alkylated DNA repair protein AlkB; Function unclear. | 0.535 |
| apbA1 | panB | azo0192 | azo3144 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.760 |
| apbA1 | panC | azo0192 | azo3145 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.733 |
| apbA1 | yueD | azo0192 | azo0189 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Putative benzil reductase. Homology to yueD of B. cereus of 32% (trembl|Q8RJ14). Belongs to the short-chain dehydrogenases/reductases (SDR) family. Transform benzil to (S)-benzion. Interpro: short-chain dehydrogenase/reductase SDR (IPR002198) Pfam: short chain dehydrogenase (PF00106) no signal peptide no TMHs; Family membership. | 0.409 |
| apbA2 | alkB | azo1994 | azo2293 | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | DNA-directed DNA polymerase; Alkylated DNA repair protein.Probably involved in the repair of alkylated DNA. Provides extensive resistance to alkylating agents.; High confidence in function and specificity. | 0.535 |
| apbA2 | apbA1 | azo1994 | azo0192 | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.727 |
| apbA2 | azo1246 | azo1994 | azo1246 | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | Conserved hypothetical mandelate racemase. Homology to bll6730 of B. japonicum of 76% (trembl|Q89FH0) Mandelate racemase and muconate lactonizing enzyme are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures. InterPro: Mandelate racemase/muconate lactonizing enzyme family (IPR001354) Pfam: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain; Specific [...] | 0.484 |
| apbA2 | azo2783 | azo1994 | azo2783 | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | DNA repair system specific for alkylated DNA; Probable RNA-directed RNA polymerase (EC 2.7.7.48) (RNA replicase) (216.5 kDa protein) (ORF1). alkb: alkylated DNA repair protein AlkB; Function unclear. | 0.535 |
| apbA2 | panB | azo1994 | azo3144 | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.740 |
| apbA2 | panC | azo1994 | azo3145 | Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (KPA reductase) (KPR). Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). apbA_panE: 2-dehydropantoate 2-reductase; Specificity unclear. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.698 |
| azo0190 | apbA1 | azo0190 | azo0192 | Conserved hypothetical protein. Homology to an orf of R. oxalatica of 31% (trembl|Q84ES1). Pfam: 37-kD nucleoid-associaed bacterial protein The Escherichia coli nucleoid contains DNA in a condensed but functional form. Analysis of proteins released from isolated spermidine nucleoids after treatment with DNase I reveals significant amounts of two proteins not previously detected in wild-type Escherichia coli. Partial amino-terminal sequencing has identified them as the products of rdgC and yejK. no signal peptide no TMHs. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.561 |
| azo0190 | azo0191 | azo0190 | azo0191 | Conserved hypothetical protein. Homology to an orf of R. oxalatica of 31% (trembl|Q84ES1). Pfam: 37-kD nucleoid-associaed bacterial protein The Escherichia coli nucleoid contains DNA in a condensed but functional form. Analysis of proteins released from isolated spermidine nucleoids after treatment with DNase I reveals significant amounts of two proteins not previously detected in wild-type Escherichia coli. Partial amino-terminal sequencing has identified them as the products of rdgC and yejK. no signal peptide no TMHs. | Conserved hypothetical protein; Entry name TREMBL:Q988L8 Prim. accession # Q988L8 InterPro IPR002539; MaoC_dehydratas. Identities = 63/131 (48%) Pfam PF01575; MaoC_dehydratas; 1. Number of predicted TMHs: 0 Probable MaoC protein (Phenylacetic acid degradation protein paaZ). | 0.561 |
| azo0190 | yueD | azo0190 | azo0189 | Conserved hypothetical protein. Homology to an orf of R. oxalatica of 31% (trembl|Q84ES1). Pfam: 37-kD nucleoid-associaed bacterial protein The Escherichia coli nucleoid contains DNA in a condensed but functional form. Analysis of proteins released from isolated spermidine nucleoids after treatment with DNase I reveals significant amounts of two proteins not previously detected in wild-type Escherichia coli. Partial amino-terminal sequencing has identified them as the products of rdgC and yejK. no signal peptide no TMHs. | Putative benzil reductase. Homology to yueD of B. cereus of 32% (trembl|Q8RJ14). Belongs to the short-chain dehydrogenases/reductases (SDR) family. Transform benzil to (S)-benzion. Interpro: short-chain dehydrogenase/reductase SDR (IPR002198) Pfam: short chain dehydrogenase (PF00106) no signal peptide no TMHs; Family membership. | 0.545 |