Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
azo0201Arylesterase (EC 3.1.1.2) (Aryl-ester hydrolase) pir:C75401:39% identity, 52% similarity:hydrolase-related protein - Deinococcus radiodurans. IS A BIFUNCTIONAL ENZYME CAPABLE OF BOTH ESTER HYDROLYSIS AND HALOGENATION. ACTS ON MANY PHENOLIC ESTERS. Pfam: PF00561: alpha/beta hydrolase fold (74-271) InterPro: IPR000073: Alpha/beta hydrolase fold IPR000379: Esterase/lipase/thioesterase Pfam:Zn binding dehydrogenase mobB: molybdopterin-guanine dinucleotid; Family membership. (271 aa)    
Predicted Functional Partners:
lpdA
Dihydrolipoamide dehydrogenase. Homology to lpdA of N. meningitides of 70% (trembl|Q59099). THE BRANCHED-CHAIN ALPHA-KETO DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF ALPHA-KETO ACIDS TO ACYL-COA AND CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS: BRANCHED-CHAIN ALPHA-KETO ACID DECARBOXYLASE (E1) LIPOAMIDE ACYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3) (BY SIMILARITY). InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327); Pyridine nucleotide-disulphide oxidoreductase, classI (IPR001100); biotin/Lipoyl attachment (IPR000089) [...]
    
 0.748
odhA
Probable 2-oxoglutarate dehydrogenase. Homology to odhA of A. eutrophus of 63% (sprot|ODO1_ALCEU). THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF 2-OXOGLUTARATE TO SUCCINYL-COA & CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS: 2-OXOGLUTARATE DEHYDROGENASE (E1) DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3). InterPro: Dehydrogenase E1 component (IPR001017); Transletolase (IPR005474) Tigrfam: 2oxo_dh_E1: 2-oxoglutarate dehydrogenase, E1 component Pfam: Dehydrogenase E1 component, Transketolas, pyridine binding domain [...]
    
  0.691
azo3056
Probable enoyl-coa-hydratase/isomerase; Activity:- (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O Entry name :- TREMBL:Q84HH6 InterPro :-IPR001753; EnCoA_hydrtse. Pfam:- PF00378; ECH; 1. Number of predicted TMHs: 0 Identities = 452/553 (81%); Family membership.
  
 
  0.679
ooxA
Putative opine oxidase subunit A. Homology to ooxA of A. tumefaciens of 37% (sprot|OOXA_AGRT4). OXIDATIVE CLEAVAGE OF OCTOPINE INTO L-ARGININE AND PYRUVATE (BY SIMILARITY). InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327), NAD-bining site (IPR000205) Pfam: Pyridine nucleotide-disulphide oxidoreductase no signal peptide no TMHs; Family membership.
    
 0.652
soxF
Probable sulfide dehydrogenase, falvoprotein subunit (Flavocytochrome C flavoprotein subunit). Homology to fccB of C. vinosum of 40% (sprot|DHSU_CHRVI). Pfam: Pyridine nucleotide-disulphide oxidoreductase signal peptide no TMHs; Family membership.
    
 0.652
pdhB
Probable dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
  0.612
odhB
Dihydrolipoamide S-succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
     
  0.612
azo3870
Hypothetical protein. Homology of the entire orf to the C-terminus of dihydrolipoamide acetyltransferase. Pfam: 2-0xo acid dehydrogenase acyltransferase no TMHs no signal peptide.
     
  0.612
azo1466
Putative superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
   
 0.607
prsA
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.604
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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