STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
aldHPutative aldehyde dehydrogenase (NAD+) (EC 1.2.1.3). Homology to adlH of E. coli of 35% (sprot|DHAL_ECOLI). Aldehyde dehydrogenases (EC: 1.2.1.3 and EC: 1.2.1.5) are enzymes which oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. InterPro: Aldehyde dehydrogenase family (IPR002086) Pfam: Aldehyde dehydrogenase family no signal peptide no TMHs; High confidence in function and specificity. (494 aa)    
Predicted Functional Partners:
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
  
 
 0.791
ordL
This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase,Sarcosine oxidase beta subunit, D-alanine oxidase, D-aspartate oxidase. Similar to trembl|Q88AY5 (61%) and to sprot|ORDL_ECOLI (32%). Pfam (PF01266): D-amino acid oxidase ProSite (PS50205): NAD binding site; Family membership.
 
 
 0.727
hadL
Probable 2-haloalkanoic acid dehalogenase (EC 3.8.1.2) (L-2-haloacid dehalogenase) (Halocarboxylic acid halidohydrolase). TREMBL:Q92Y68: 68% identity, 82% similarity These proteins catalyze the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids [1]. They belong to the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases InterPro:IPR006328; HAD_II. IPR006388; HAD_SF_IA_v2. IPR005834; Hydrolase. Pfam PF00702; Hydrolase rpiB_lacA_lacB: sugar-phosphate isomer No signal peptide No transmembrane helices; High [...]
  
  0.697
acS1
Acetyl-coenzyme A synthetase enables the cell to use acetate during aerobic growth to generate energy via the tca cycle, and biosynthetic compounds via the glyoxylate shunt. acetylates chey, the response regulator involved in flagellar movement and chemotaxis. Entry name SWISSPROT:ACSA_ECOLI Prim. accession # P27550 Identities = 145/546 (26%) Pfam PF00501; AMP-binding; 1. InterPro IPR000873; AMP-bind. Pfam PF00501; AMP-binding; 1. Number of predicted TMHs: 0; Family membership.
   
 0.691
acsA
Putative acetoacetyl-CoA synthase; INVOLVED IN POLY-3-HYDROXYBUTYRATE DEGRADATION. ACTIVATES ACETOACETATE TO ACETOACETYL-COA. catalytic activity :-atp + acetate + coa = amp + diphosphate + acetyl-coa. Entry name SWISSPROT:ACSA_ECOLI Prim. accession # P27550 Identities = 164/624 (26%) InterPro IPR000873; AMP-bind. Pfam PF00501; AMP-binding; 1. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership.
   
 0.691
acsB
Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.691
putA
Probable bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
 
0.688
azo0214
Conserved hypothetical acetyltransferase. Homology to putative acetaltransferase (GNAT family) of P. syringae of 42% (trembl|Q88AY8). Pfam: Acetyltransferase (GNAT) family no signal peptide no TMHs; Family membership.
 
     0.658
maeB1
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40) (NADP-ME). Homology to dme of S. meliloti of 60% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. Tigrfam: pta: phosphotransacetylase Pfam: Malic enzyme; Phosphate acetyl/butaryltransferase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.651
maeB2
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). Homology to dme of S. meliloti of 61% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. InterPro: Phosphate acetyl/butaryl transferase (IPR002505); Malic enzyme (IPR001891) Pfam: Malic enzyme; Phosphate acetyl/butaryl transferase Tigrfam: pta: phosphotransacetylase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.651
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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