Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
czcBPutative membrane fusion protein. Homology to cnrb of A. eutrophus of 30% (pir|F47056). Proteins of the MFP family function as auxiliary proteins or 'adaptors',connecting a primary porter in the cytoplasmic membrane of a Gram-negative bacterium with an outer membrane factor protein that serves a porin or channel function in the outer membrane. In A. eutrophus is this protein involved in cobalt and nickel resistance. No domains predicted. No signal peptide No TMHs; Family membership. (352 aa)    
Predicted Functional Partners:
czcA2
Cobalt-zinc-cadmium resistance protein CzcA (cation efflux system protein CzcA). In A.eutrophus has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance.Czca and Czcb together would act in zinc efflux nearly as effectively as the complete czc efflux system (czcABC).Belongs to the acrb/acrd/acrf family. 41% similarity to the A.eutrophus CzcA protein. SWISSPROT:CZCA_ALCEU:P13511 InterPro: Heavy metal efflux pump CzcA. InterPro:IPR001036; Acrflvin_res.IPR004763: CzcA. Pfam:PF00873; ACR_tran; 1. InterPro:TIGR00914:Heavy meta [...]
 
 0.982
azo0270
Hypothetical secreted protein. Homology to cnfc of Ralstonia sp CH34 of 28% (tremblnew|CAB82451(SRS). Pfam: outer membrane protein. Interpro: Type I antifreeze protein (IPR000104). singal peptide. no TMHs.
 
  0.970
macB
ATP-binding/permease fusion ABC transporter; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 0.953
azo0269
Conserved hypothetical protein.30% identical to TrEMBL; Q89MS9. Signal Peptide present.
 
     0.925
azo0224
Hypotethical outer membrane efflux protein. Homology to PA2525 of P. aeruginosa of 25%. signal peptide. no TMHs.
  
  0.855
tolC
Putative outer membrane effluxe protein protein. Homology to tolC from E. coli of 33%. The OEP family (outer membreane effluxe protein) allow export of a variety of substrates in Gram negative bacteria. TolC is believed to be a membre af an ABC transporter system for protein secretion without cleavage of a signal sequence. Pfam: Outer membrane efflux protein Signal peptide no TMHs; Family membership.
 
 0.853
azo2955
Putative cation efflux system protein; Region start changed from 3242195 to 3242423 (-228 bases); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 0.853
aggA
Putative outer membrane efflux protein. Homology to aggA from P. putida of 35%. The OEP family (outer membrane efflux protein) allow export of a variety of substrates in Gram negative bacteria. InterPro: Outer membrane efflux protein Pfam: Outer membrane efflux protein signal peptide no TMHs; Function unclear.
  
 0.850
czcA1
Cobalt-zinc-cadmium resistance protein CzcA (cation efflux system protein CzcA). In A.eutrophus has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance.Czca and Czcb together would act in zinc efflux nearly as effectively as the complete czc efflux system (czcABC).Belongs to the acrb/acrd/acrf family. 41% similarity to the A.eutrophus CzcA protein. SWISSPROT:CZCA_ALCEU:P13511 InterPro: Heavy metal efflux pump CzcA. InterPro:IPR001036; Acrflvin_res.IPR004763: CzcA. Pfam:PF00873; ACR_tran; 1. InterPro:TIGR00914:Heavy meta [...]
 
 0.846
azo3134
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q9HW27 (38% identity); SWISSPROT:Q57124 (33% identity). InterPro (IPR001036): Acriflavin resistance protein. Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. TMHMM [...]
  
 0.810
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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