Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
azo0296InterPro:IPR001279- Metallo-beta-lactamase superfamily,glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. TREMBL:Q7WEK1-55% Identity. Pfam-Presence of phosphoribosyltransferase, tissue factor, and GMP reductaseC like domains Signal P predicting signal peptide and TMHMM predicting transmembrane helices. ccoP: cytochrome c oxidase cbb3-type s; High confidence in function and specificity. (326 aa)    
Predicted Functional Partners:
azo3948
Putative DNA-directed polymerase III; Excinuclease cho (EC 3.1.25.-) (Endonuclease cho) (UvrC homolog protein). Incises the DNA at the 3 side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than uvrC. Not able to incise the 5 site of a lesion. When a lesion remains because uvrC is not able to induce the 3 incision cho incises the DNA. Then uvrC makes the 5 incision. The combined action of cho and uvrC broadens the substrate range of nucleotide excision repair (By similarity); Specificity unclear.
    
 0.628
azo1211
Conserved hypothetical protein. Homology bll7767 of B. japonicum of 30% (trembl|Q89CN0) Pfam: WD domain, G-beta repeat no signal peptide no TMHs.
    
  0.602
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
     
 0.601
FtsJ
Ribosomal RNA large subunit methyltransferase j; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
     
  0.589
rplJ
50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
     
  0.589
azo2202
Probable DNA polymerase III, epsilon subunit,23% Identity to TrEMBL;Q8KDK8. Has EXOIII,SMART;SM00479;IPR006054, DnaQ;This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III. Ribonuclease T is responsible for the end-turnover of tRNA,and removes the terminal AMP residue from uncharged tRNA. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria, and also exhibits 3' to 5' exonuclease activity.
 
  
 0.585
azo0709
Putative exoribonuclease II (EC: 3.1.13.1), RNase R.
     
  0.557
vacB
Exoribonuclease II; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
     
  0.557
polC
DNA polymerase III polC-type (EC 2.7.7.7) (PolIII). Required for replicative DNA synthesis. This DNA polymerase also exhibits 3 to 5 exonuclease activity (By similarity). InterPro: Exonuclease dnaq: DNA polymerase III epsilon subun; High confidence in function and specificity.
    
 0.525
dnaQ
DNA-directed DNA polymerase; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
    
 0.525
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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