STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
paaZConserved hypothetical dehydrogenase. Homology to paaZ of A. evansii of 83% (trembl|Q9F9V2). Pfam: Aldehyde dehydrogenase family no signal peptide no TMHs; Family membership. (554 aa)    
Predicted Functional Partners:
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
  
 
 0.791
paaK
Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).
 
 
 0.774
paaI
Phenylacetic acid degradation protein PaaI; Phenylacetic acid aerobic catabolism. Similar to TREMBL:Q9F9V0 (74% identity); SWISSPROT:P76084 (48% identity). InterPro (IPR003736): Phenylacetic acid degradation-related protein. Pfam (DUF157): Uncharacterized protein PaaI, COG2050; High confidence in function and specificity.
 
  
 0.732
paaH1
Probable 3-hydroxybutyryl-CoA dehydrogenase; Activity:-3-acetoacetyl-CoA + NADPH = (S)-3-hydroxybutanoyl-CoA + NADP+ Entry name TREMBL:Q9F9V1 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR002110; ANK. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 2. PF02737; 3HCDH_N; 1. Identities = 344/510 (67%) Prediction: Signal peptide Signal peptide probability: 0.660 Number of predicted TMHs: 1; High confidence in function and specificity.
 
 0.691
putA
Probable bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
 
0.668
paaG1
Probable enoyl-CoA hydratase. Homology to paaG of E. coli of 60% (sprot|PAAG_ECOLI(SRS) COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS (BY SIMILARITY). Activity:- (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. Interpro: Enoyl-CoA hydratase/isomerase (IPR001753) Pfam: Enoyl-CoA hydratase/isomerase no signal peptide no TMHs; High confidence in function and specificity.
 
  
 0.652
maeB1
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40) (NADP-ME). Homology to dme of S. meliloti of 60% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. Tigrfam: pta: phosphotransacetylase Pfam: Malic enzyme; Phosphate acetyl/butaryltransferase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.651
maeB2
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). Homology to dme of S. meliloti of 61% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. InterPro: Phosphate acetyl/butaryl transferase (IPR002505); Malic enzyme (IPR001891) Pfam: Malic enzyme; Phosphate acetyl/butaryl transferase Tigrfam: pta: phosphotransacetylase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.651
paaY
Probable phenyl acetic acid degradation protein; Pathway:carnitine metabolism (conversion of carnitine to gamma-butyrobetaine). TREMBL:Q9F9V3: 71% identity, 83% similarity similarity:belongs to the transferase hexapeptide repeat family Carnitine operon protein caiE. InterPro:IPR001451; Hexapep_transf. Pfam:PF00132; Hexapep InterPro: Bacterial transferase hexapeptide repeat TIGR00094: conserved hypothetical protein; High confidence in function and specificity.
     
 0.648
pta
Conserved hypothetical phosphate acetyltransferase. Homology to pta of R. palustris of 63% (tremblnew|CAE30007). InterPro: Phosphate acetyl/butaryl transferase (IPR002505); MaoC-like dehydrogenase domain (IPR002539). Pfam: MaoC like domain; Phosphate acetyl/butaryl transferase. no signal peptide. no TMHs; Conserved hypothetical protein.
 
 
 0.634
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.