STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
paaIPhenylacetic acid degradation protein PaaI; Phenylacetic acid aerobic catabolism. Similar to TREMBL:Q9F9V0 (74% identity); SWISSPROT:P76084 (48% identity). InterPro (IPR003736): Phenylacetic acid degradation-related protein. Pfam (DUF157): Uncharacterized protein PaaI, COG2050; High confidence in function and specificity. (156 aa)    
Predicted Functional Partners:
paaA
Phenylacetic acid degradation protein [paaA],86% identity(91% similarity) to TrEMBL;Q9F9U9. 72% identity to TrEMBL;Q7WGX6, Q8XS77 Has PF05138, Phenylacetic acid catabolic protein;IPR007814, PaaA_PaaC; This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex. No Signal Peptide or TMH present; High confidence in function and specificity.
 
 
 0.990
paaD
Probable pheylacetic acid degradation protein PaaD. Homology to phaH of P. putida of 54% (trembl|Q88HS8) Interpro: Protein of unknown function DUF59 (IPR002744) Pfam: Domain of unknoen function DUF59 (PF01883). Domain of unknown function DUF59;IPR002744; This family includes prokaryotic proteins of unknown function. The family also includes PhaH O84984 from Pseudomonas putida. PhaH forms a complex with PhaF O84982, PhaG O84983 and PhaI O84985,which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid. So members of this family may all be components of ring hydroxylating complex [...]
 
 
 0.987
paaE
Probable phenylacetic acid degradation NADH oxidoreductase paaE. Homology to paaE of E. coli of 50% (sprot|PAAE_ECOLI). Probable PART OF A MULTICOMPONENT OXYGENASE involved in aerobic degradation of phenylacetic acid. InterPro: Oxidoreductase FAD and NAD(P)-binding domain(IPR001433); 2Fe-2S Ferredoxin (IPR006057); Ferredoxin (IPR001041); NADH: cytochrome b5 reductase (CBR) (IPR001834) Pfam: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain; 2Fe-2S iorn-sulfur cluster binding domain no signal peptide no TMHs; High confidence in function and specificity.
 
 
  0.985
paaB
Phenylacetic acid degradation protein PaaB; May be part of a multicomponent oxygenase involved in phenylacetyl-coa hydroxylation. Phenylacetic acid aerobic catabolism pathway, TREMBL:Q8XS76 (75% identity); SWISSPROT:P76078 (61% identity); High confidence in function and specificity.
 
 
 0.968
paaK
Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).
 
 
 0.961
paaC
Probable phenylacetic acid degradation protein PaaC. Homology to paaI of P. putida of 46% (trembl|O84983). Part of a catabolic pathway of phenylacetic acid. These proteins forms part of a dioxygenase complex. Interpro: Phenylacetic acid catabolic (IPR007814) Pfam: Phenylacetic acid catabolic protein (PF05138) no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.953
paaG1
Probable enoyl-CoA hydratase. Homology to paaG of E. coli of 60% (sprot|PAAG_ECOLI(SRS) COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS (BY SIMILARITY). Activity:- (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. Interpro: Enoyl-CoA hydratase/isomerase (IPR001753) Pfam: Enoyl-CoA hydratase/isomerase no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.929
thmS1
Probable succinate semialdehyde dehydrogenase [NAD(P)+). Homology to thmS of Pseudonocardia sp. K1 of 55% (trembl|Q9F3V7). Is capable of oxidizing substrates using NADP as cofactor. InterPro: Aldehyde dehydrogenase family (IPR002086) Pfam: Aldehyde dehydrogenase family no signal peptide no TMHs; Family membership.
     
 0.929
paaH1
Probable 3-hydroxybutyryl-CoA dehydrogenase; Activity:-3-acetoacetyl-CoA + NADPH = (S)-3-hydroxybutanoyl-CoA + NADP+ Entry name TREMBL:Q9F9V1 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR002110; ANK. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 2. PF02737; 3HCDH_N; 1. Identities = 344/510 (67%) Prediction: Signal peptide Signal peptide probability: 0.660 Number of predicted TMHs: 1; High confidence in function and specificity.
  
 0.870
padB
Conserved hypothetical phenylacetyl-CoA:acceptor oxidoreductase. Homology to padB of Azoarcus sp. EbN1 of 58% (gnl|keqq|eba:ebA5393(KEGG)). InterPro: Prokaryotic molybdopterin oxidoreductases (IPR006655). Pfam: Molypdopterin oxidoreductase; Molydopterin dinucleotide binding domain. no signal peptide. no TMHs; Function unclear.
    
  0.870
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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