STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
paaEProbable phenylacetic acid degradation NADH oxidoreductase paaE. Homology to paaE of E. coli of 50% (sprot|PAAE_ECOLI). Probable PART OF A MULTICOMPONENT OXYGENASE involved in aerobic degradation of phenylacetic acid. InterPro: Oxidoreductase FAD and NAD(P)-binding domain(IPR001433); 2Fe-2S Ferredoxin (IPR006057); Ferredoxin (IPR001041); NADH: cytochrome b5 reductase (CBR) (IPR001834) Pfam: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain; 2Fe-2S iorn-sulfur cluster binding domain no signal peptide no TMHs; High confidence in function and specificity. (355 aa)    
Predicted Functional Partners:
paaB
Phenylacetic acid degradation protein PaaB; May be part of a multicomponent oxygenase involved in phenylacetyl-coa hydroxylation. Phenylacetic acid aerobic catabolism pathway, TREMBL:Q8XS76 (75% identity); SWISSPROT:P76078 (61% identity); High confidence in function and specificity.
 
 
 0.986
paaC
Probable phenylacetic acid degradation protein PaaC. Homology to paaI of P. putida of 46% (trembl|O84983). Part of a catabolic pathway of phenylacetic acid. These proteins forms part of a dioxygenase complex. Interpro: Phenylacetic acid catabolic (IPR007814) Pfam: Phenylacetic acid catabolic protein (PF05138) no signal peptide no TMHs; High confidence in function and specificity.
 
 0.985
paaD
Probable pheylacetic acid degradation protein PaaD. Homology to phaH of P. putida of 54% (trembl|Q88HS8) Interpro: Protein of unknown function DUF59 (IPR002744) Pfam: Domain of unknoen function DUF59 (PF01883). Domain of unknown function DUF59;IPR002744; This family includes prokaryotic proteins of unknown function. The family also includes PhaH O84984 from Pseudomonas putida. PhaH forms a complex with PhaF O84982, PhaG O84983 and PhaI O84985,which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid. So members of this family may all be components of ring hydroxylating complex [...]
 
 
 0.981
paaA
Phenylacetic acid degradation protein [paaA],86% identity(91% similarity) to TrEMBL;Q9F9U9. 72% identity to TrEMBL;Q7WGX6, Q8XS77 Has PF05138, Phenylacetic acid catabolic protein;IPR007814, PaaA_PaaC; This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex. No Signal Peptide or TMH present; High confidence in function and specificity.
 
 0.980
paaI
Phenylacetic acid degradation protein PaaI; Phenylacetic acid aerobic catabolism. Similar to TREMBL:Q9F9V0 (74% identity); SWISSPROT:P76084 (48% identity). InterPro (IPR003736): Phenylacetic acid degradation-related protein. Pfam (DUF157): Uncharacterized protein PaaI, COG2050; High confidence in function and specificity.
 
 
 0.966
hoxF
Probable hydrogen dehydrogenase, alpha subunit. Homology to hoxF of A. eutrophus of 41% (sprot|HOXF_ALCEU). SUBUNITS ALPHA AND GAMMA OF HOXS CONSTITUTE AN NADH-OXIDOREDUCTASE. InterPro: Respiratory-chain NADH dehydrogenase 51 Kd subunit (IPR001949); Respiratory-chain NADH dehydrogenase 24 Kd subunit (IPR002023) Pfam: Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit no signal peptide no TMHs; High confidence in function and specificity.
  
 0.965
fdh1B
Probable formate dehydrogenase (NADP+), beta subunit Homology to fdh1B of M. extorpuens of 55% (trembl|Q8KTI8) Pfam: Respiratory-chain NADH dehydrogenase 24 kD subunit; Respiratory-chain NADH dehydrogenase 51 kD subunit. no signal peptide no TMHs; High confidence in function and specificity.
  
 0.965
nifU
Probable nitrogen fixation protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 0.946
azo0114
Conserved hypothetical protein. Homology to bp2124 of B. pertussis of 48% (trembl|Q7VWS5). Pfam: Pyridoxamine 5-phosphate oxidase no signal peptide no TMHs.
      0.872
abmA
2-amninobenzoyl-CoA monooxygenase/reductase (EC 1.14.13.40) Homology to abmA of A. evansii of 86% (trembl|Q93FB8(SRS). natural fusion protein of a monooxygenase and a reductase; contains flavin. Pfam: Monooxygnease; NADH:flavin oxidoreductase/NADH oxidorecutase. no signal peptide. no TMHs; High confidence in function and specificity.
    
 0.865
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.