STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
paaRPutative TetR family transcriptional regulator,; Family membership. (214 aa)    
Predicted Functional Partners:
paaE
Probable phenylacetic acid degradation NADH oxidoreductase paaE. Homology to paaE of E. coli of 50% (sprot|PAAE_ECOLI). Probable PART OF A MULTICOMPONENT OXYGENASE involved in aerobic degradation of phenylacetic acid. InterPro: Oxidoreductase FAD and NAD(P)-binding domain(IPR001433); 2Fe-2S Ferredoxin (IPR006057); Ferredoxin (IPR001041); NADH: cytochrome b5 reductase (CBR) (IPR001834) Pfam: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain; 2Fe-2S iorn-sulfur cluster binding domain no signal peptide no TMHs; High confidence in function and specificity.
 
   
 0.743
paaD
Probable pheylacetic acid degradation protein PaaD. Homology to phaH of P. putida of 54% (trembl|Q88HS8) Interpro: Protein of unknown function DUF59 (IPR002744) Pfam: Domain of unknoen function DUF59 (PF01883). Domain of unknown function DUF59;IPR002744; This family includes prokaryotic proteins of unknown function. The family also includes PhaH O84984 from Pseudomonas putida. PhaH forms a complex with PhaF O84982, PhaG O84983 and PhaI O84985,which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid. So members of this family may all be components of ring hydroxylating complex [...]
 
     0.686
paaJ1
THIOLYTIC CLEAVAGE OF BETA-KETOADIPYL-COA TO SUCCINATE AND ACETYL-COA. Entry name:- TREMBL:Q84HH5 InterPro:- IPR002155; Thiolase. Pfam:- PF02803; Thiolase_C; 1. PF00108; Thiolase_N; 1. Identities = 298/398 (74%) Number of predicted TMHs: 0; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.
       0.624
paaC
Probable phenylacetic acid degradation protein PaaC. Homology to paaI of P. putida of 46% (trembl|O84983). Part of a catabolic pathway of phenylacetic acid. These proteins forms part of a dioxygenase complex. Interpro: Phenylacetic acid catabolic (IPR007814) Pfam: Phenylacetic acid catabolic protein (PF05138) no signal peptide no TMHs; High confidence in function and specificity.
 
     0.610
mhpA
Putative oxygenase. 3-(3-hydroxy-phenyl)propionate hydroxylase (EC 1.14.13.-), InterPro: Aromatic-ring hydroxylase (flavoprotein monooxygenase); Specificity unclear.
  
     0.575
paaB
Phenylacetic acid degradation protein PaaB; May be part of a multicomponent oxygenase involved in phenylacetyl-coa hydroxylation. Phenylacetic acid aerobic catabolism pathway, TREMBL:Q8XS76 (75% identity); SWISSPROT:P76078 (61% identity); High confidence in function and specificity.
 
     0.560
azo3680
Conserved hypothetical protein. Homology to RS01748 of R.solanacearum of 59% (trembl:Q8XRY0). No domains predicted. No TMHs. No signal peptide.
  
     0.514
paaA
Phenylacetic acid degradation protein [paaA],86% identity(91% similarity) to TrEMBL;Q9F9U9. 72% identity to TrEMBL;Q7WGX6, Q8XS77 Has PF05138, Phenylacetic acid catabolic protein;IPR007814, PaaA_PaaC; This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex. No Signal Peptide or TMH present; High confidence in function and specificity.
 
     0.506
paaI
Phenylacetic acid degradation protein PaaI; Phenylacetic acid aerobic catabolism. Similar to TREMBL:Q9F9V0 (74% identity); SWISSPROT:P76084 (48% identity). InterPro (IPR003736): Phenylacetic acid degradation-related protein. Pfam (DUF157): Uncharacterized protein PaaI, COG2050; High confidence in function and specificity.
 
     0.456
azo3682
Putative cyclase; Beta-lactamase II precursor (EC 3.5.2.6) (Penicillinase) (Cephalosporinase). Can hydrolyze carbapenem compounds. InterPro:IPR001279-Metallo-beta-lactamase superfamily TREMBL:Q8XRX8-72% identity TREMBL:Q7VUG6- 62% Pfam:PF00753-LactamaseB, Ribosomal proteinS6e,ThiC family TIGRFAM:TIGR00010- TatD/hisF family TMHMM predicted transmembrane helix. mobB: molybdopterin-guanine dinucleotide; High confidence in function and specificity.
  
     0.452
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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