Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cutA1Periplasmic divalent cation tolerance protein .36% similarity to E.coli CutA1 protein involved in copper tolerance. InterPro:IPR004323; CutA1. Pfam:PF03091; CutA1; 1; High confidence in function and specificity. (107 aa)    
Predicted Functional Partners:
cutA2
Putative protein disulfide-isomerase; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.
  
  
 0.763
naoA
2-nitropropane dioxygenase; TREMBL:Q7MBF3: 80% identity, 89% similarity InterPro:IPR004136; 2nprop_dioxygen. IPR003009; FMN_enzyme. Pfam: PF03060; NPD tim: triosephosphate isomerase Non-secretory protein with no signal peptide. TMHMM predicted no transmembrane helices.; High confidence in function and specificity.
       0.636
azo1032
Conserved hypothetical protein; TREMBL:Q8XZ43; 52% identity, 70% similarity. TREMBL:Q8F5Y8; 30% identity, 56% similarity. Protein At5g10860 mitochondrial precursor. IPR000644: CBS domain Pfam:PF00571 - GARS_N TIGRFAM: rrf2 family, KpsF/GutQ family (by similarity) kpsF: KpsF/GutQ family protein; Specificity unclear.
  
   0.613
ribAB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
       0.577
azo1748
Hypothetical protein yhcV. TREMBL:Q92V69:54%identity, 76% similarity. TREMBL:Q81UY6 Pfam:CBS domain, Anticodon binding domain. TIGRFAM: KpsF/GutQ family proteins. No signal peptide or transmembrane helix reported. CBS domains are small intracellular modules of unknown function. They are mostly found in 2 or four copies within a protein. Pairs of CBS domains dimerise to form a stable globular domain. Two CBS domains are found in inosine-monophosphate dehydrogenase from all species, however the CBS domains are not needed for activity. CBS domains are found attached to a wide range of oth [...]
   
   0.563
ribE
Riboflavin synthase alpha chain (EC 2.5.1.9). Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1-D)- ribityl-amino-24(1H3H)-pyrimidinedione and L-34-dihydrohy-2- butanone-4-phosphate via 67-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 67-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1-D)-ribityl-amino-24(1H3H)- pyrimidinedione. ribE: riboflavin synthase alpha subunit; High confidence in function and specificity.
       0.536
acpS
Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
    
  0.509
coaD
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
     
  0.505
ribH
Riboflavin synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
       0.442
nusB
Putative N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
       0.441
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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