STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
blaAProbable transcriptional regulator, LysR family; HTH-type transcriptional regulator blaA (Beta-lactamase regulatory protein blaA). Positive regulator of the expression of the gene (blab) for beta-lactamase. Similar to SWISSPROT: sprot|BLAA_PROVU (32% Proteus vulgaris, HTH-type transcriptional regulator BlaA) InterPro: IPR000847 HTH_LysR. IPR009058 Winged helix DNA-binding. Pfam: PF00126 Bacterial regulatory helix-turn-helix protein, lysR family. HTH reporting nucleic acid binding motif; High confidence in function and specificity. (331 aa)    
Predicted Functional Partners:
azo1835
Transcriptional regulator, LysR family,; Specificity unclear; Belongs to the LysR transcriptional regulatory family.
  
     0.704
gstR1
Putative transcriptional regulator. Homology to gstR of R. leguminosarum of 37% (tremble:Q52827). Has PF00126, HTH_1,Bacterial regulatory helix-turn-helix protein, lysR family.IPR000847, HTH_LysR; Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC,iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR,nodD, [...]
  
     0.702
gltR
Probable transcriptional regulator, LysR family; HTH-type transcriptional regulator gltR. POSITIVE REGULATOR OF GLUTAMATE BIOSYNTHESIS (GLTAB GENES). NEGATIVELY REGULATES ITS OWN EXPRESSION. Similar to SWISSPROT: sprot|GLTR_BACSU (33% Bacillus subtilis, HTH-type transcriptional regulator GltR) InterPro: IPR000847 HTH_LysR. IPR009058 Winged helix DNA-binding. Pfam: PF00126 Bacterial regulatory helix-turn-helix protein,lysR family. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.701
azo2367
Transcriptional regulator, LysR family,; Function unclear; Belongs to the LysR transcriptional regulatory family.
  
     0.699
azo0329
Conserved hypothetical protein. Homology to SCO5300 of Streptomyces coelicolor of 46% (tremble:Q9XAE9). No domains predicted. No TMHs. No signal peptide.
 
     0.651
azo2992
Probable transcriptional regulator, LysR family,; Family membership; Belongs to the LysR transcriptional regulatory family.
  
     0.580
azo1281
Probable transcriptional regulator, LysR family proteins.57% Identity to TrEMBL;Q9HYK6, Q87XZ5, Q88MD6. Has PF03466, LysR substrate binding domain;IPR005119,LysR_subst; The structure of this domain is known and is IPR000847, HTH_LysR; Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family,groups together a range of proteins, including ampR, catM,catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR [...]
  
     0.506
azo2360
Transcriptional regulator, LysR family,; Specificity unclear; Belongs to the LysR transcriptional regulatory family.
  
     0.502
azo0331
Conserved hypothetical protein, 41% similarity to TrEMBL;Q88JC7. Has IPR005544 DUF_HHE:PF03794;Domain of Unknown function:This domain normally occurs as tandem repeats and is found in bacteria, yeast and plants. It contains two fully conserved histidines and one glutamate residue. Members of the family include DnrN, NorA and ScdA, which have been implicated in NO response and cell wall physiology. Has no Signal peptide or TMH reported present.
       0.482
rpoA
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.462
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (30%) [HD]