STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fadAxProbable acyl-CoA thiolase. Homology to fadAx of P. putida of 67% (gnl|keqq|ppu:PP2215(KEGG)). IPR002155; Thiolase. Pfam PF02803; Thiolase_C; 1. PF00108; Thiolase_N; 1. Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC:2.3.1.9) and 3-ketoacyl-CoA thiolase (EC:2.3.1.16). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid -oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of a [...] (403 aa)    
Predicted Functional Partners:
fadB1
Probable enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; Alpha-subunit of fatty acid oxidation complex. Entry name TREMBL:Q8G968 Prim. accession # Q8G968 Identities = 373/642 (58%) InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0 IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1; Family membership.
 0.999
fadB2
Short-chain enoyl-CoA hydratase activity. Activity:- 3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O Entry name TREMBL:Q8P986 Prim. accession # Q8P986 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1. Identities = 468/796 (58%) Prediction: Signal peptide Signal peptide probability: 0.980 Number of predicted TMHs: 0; Family membership.
 
 0.998
hbdA
Probable 3-hydroxybutyryl-CoA dehydrogenase; Activity:- (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+ Entry name :- TREMBL:Q89GX2 Prim. accession # Q89GX2 Identities = 177/280 (63%) InterPro:- IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR000205; NAD_BS. Pfam :-PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. Prediction: Signal peptide Signal peptide probability: 0.873 Number of predicted TMHs: 0; Family membership.
 0.986
paaH2
Probable 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) (Beta- hydroxybutyryl-CoA dehydrogenase) (BHBD). Activity:- 3-acetoacetyl-CoA + NADPH = (S)-3-hydroxybutanoyl-CoA + NADP+ Entry name TREMBL:Q9F9V1 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR002110; ANK. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 2. PF02737; 3HCDH_N; 1. Identities = 319/502 (63%) Prediction: Signal peptide Signal peptide probability: 0.906 Number of predicted TMHs: 0; Family membership.
 0.979
fadfX
Probable acyl-CoA dehydrogenase; Activity:- Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. Entry name TREMBL:Q9AHX9 Prim. accession # Q9AHX9 InterPro IPR006089; Acyl-CoA_dh. IPR006090; Acyl-CoA_dh_C. IPR006091; Acyl-CoA_dh_M. IPR006092; Acyl-CoA_dh_N. IPR009075; AcylCoADH_C_like. IPR009100; AcylCoA_dehyd_NM. Pfam PF00441; Acyl-CoA_dh; 1. PF02770; Acyl-CoA_dh_M; 1. PF02771; Acyl-CoA_dh_N; 1. Identities = 244/375 (65%) Number of predicted TMHs: 0; Family membership.
 
  0.974
azo1987
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,; Specificity unclear.
  
 0.970
phbB2
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,SWISSPROT:P14697 (62% identity); TREMBL:Q8XYX3 (62% identiy). InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR). InterPro (IPR002347): Glucose/ribitol dehydrogenase. Pfam (PF00106): Short chain dehydrogenase. SignalP reporting signal peptide; High confidence in function and specificity.
 
  
  0.959
pta
Conserved hypothetical phosphate acetyltransferase. Homology to pta of R. palustris of 63% (tremblnew|CAE30007). InterPro: Phosphate acetyl/butaryl transferase (IPR002505); MaoC-like dehydrogenase domain (IPR002539). Pfam: MaoC like domain; Phosphate acetyl/butaryl transferase. no signal peptide. no TMHs; Conserved hypothetical protein.
  
 0.956
fadE
Probable acyl-CoA dehydrogenase. Homology to fadE of E. coli of 55% (trembl|Q8KTJ8(SRS)) Catalyzes the dehydrogenation of acyl-CoA (By similarity). Reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. InterPro: Acyl-CoA dehydrogenase (IPR006089) Pfam: Acyl-CoA dehydrogenase, N-terminal domain; Acyl-CoA dehydrogenase, C-terminal domain signal peptide 2 TMHs; High confidence in function and specificity.
  
  0.946
acsA
Putative acetoacetyl-CoA synthase; INVOLVED IN POLY-3-HYDROXYBUTYRATE DEGRADATION. ACTIVATES ACETOACETATE TO ACETOACETYL-COA. catalytic activity :-atp + acetate + coa = amp + diphosphate + acetyl-coa. Entry name SWISSPROT:ACSA_ECOLI Prim. accession # P27550 Identities = 164/624 (26%) InterPro IPR000873; AMP-bind. Pfam PF00501; AMP-binding; 1. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership.
  
 
 0.940
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.