Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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cheA1Putative chemotaxis histidine kinase protein,ATPbind_ATPase. IPR004358; Bact_sens_pr_C. IPR002545; CheW. IPR004105; H-kinase_dim. IPR005467; His_kinase. IPR008207; Hpt. IPR008208; Hpt_N. Pfam: PF01584; CheW. PF02895; H-kinase_dim. PF02518; HATPase_c. PF01627; Hpt. SMART: SM00260; CheW. SM00387; HATPase_c. SM00073; HPT. Chemotaxis protein cheA (EC 2.7.3.-). INVOLVED IN THE TRANSMISSION OF SENSORY SIGNALS FROM THE CHEMORECEPTORS TO THE FLAGELLAR MOTORS. CHEA IS AUTOPHOSPHORYLATED; IT CAN TRANSFER ITS PHOSPHATE GROUP TO EITHER CHEB OR CHEY; High confidence in function and specificity. (731 aa)    
Predicted Functional Partners:
cheW1
Probable positive regulator of CheA protein activity, CheW. Pfam: PF01584; CheW. SMART: SM00260; CheW. Chemotaxis protein cheW.Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges chea to the mcps (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to cheY and cheB; High confidence in function and specificity.
 
 0.997
cheV2
Probable chemotaxis protein, CheW. IPR001789; Response_reg. Pfam: PF01584; CheW. PF00072; Response_reg. SMART: SM00260; CheW. SM00448; REC. Chemotaxis protein cheV. CHEMOTAXIS INVOLVES BOTH A PHOSPHORYLATION-DEPENDENT EXCITATION AND A METHYLATION-DEPENDENT ADAPTATION. CHEV AND CHEW FUNCTION TOGETHER TO COUPLE CHEA ACTIVATION TO METHYL-ACCEPTING CHEMOTAXIS PROTEIN RECEPTOR STATUS AND POSSIBLE CHEA-DEPENDENT PHOSPHORYLATION OF CHEV CONTRIBUTES TO ADAPTATION; High confidence in function and specificity.
 
 0.995
cheB1
Probable protein glutamate-methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 0.993
cheB2
Protein glutamate-methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 0.990
cheV1
Probable chemotaxis protein, CheW. IPR001789; Response_reg. Pfam: PF01584; CheW. PF00072; Response_reg. SMART: SM00260; CheW. SM00448; REC. Chemotaxis protein cheV. CHEMOTAXIS INVOLVES BOTH A PHOSPHORYLATION-DEPENDENT EXCITATION AND A METHYLATION-DEPENDENT ADAPTATION. CHEV AND CHEW FUNCTION TOGETHER TO COUPLE CHEA ACTIVATION TO METHYL-ACCEPTING CHEMOTAXIS PROTEIN RECEPTOR STATUS AND POSSIBLE CHEA-DEPENDENT PHOSPHORYLATION OF CHEV CONTRIBUTES TO ADAPTATION; High confidence in function and specificity.
 
 0.988
cheY1
Probable chemotaxis response regulator,; High confidence in function and specificity.
 
 0.987
cheY3
Chemotaxis response regulator, Response_reg. Pfam: PF00072; Response_reg. SMART: SM00448; REC. Chemotaxis protein cheY. Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form cheY exhibits enhanced binding to a switch component fliM at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity); High confidence in function and specificity.
 
 0.987
cheW2
Positive regulator of CheA protein activity,; High confidence in function and specificity.
 
 0.986
azo0410
Putative methyl-accepting chemotaxis protein,Chmtaxis_transd. Pfam: PF00015; MCPsignal. SMART: SM00283; MA. Signal P reporting signal peptide. TMHMM reporting 2 transmembrane helices; Function unclear.
 
 0.985
tcp
Putative citrate chemoreceptor protein; Salmonella typhimurium shows an attractant response to citrate and a repellent response to phenol, and a chemoreceptor mediating these responses has been identified and named Tcp (taxis to citrate and away from phenol). Similar to sprot|MCPC_SALTY (32%)and to trembl|Q82TM2. InterPro (IPR004089): Bacterial chemotaxis sensory transducer InterPro (IPR003660): HAMP InterPro (IPR004090): Methyl-accepting chemotaxis protein InterPro (IPR001610): PAC InterPro (IPR000014): PAS_domain Pfam (PF00672): HAMP Pfam (PF00015): MCPsignal Pfam (PF00785): PAC Pfam [...]
 
 0.983
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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