node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
azo0443 | azo0445 | azo0443 | azo0445 | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity. | 0.919 |
azo0443 | azo0446 | azo0443 | azo0446 | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. | 0.918 |
azo0443 | azo1795 | azo0443 | azo1795 | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | 0.619 |
azo0443 | lig2 | azo0443 | azo0444 | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]). This protein seals during DNA replication DNA recombination and DNA repair nicks in double-stranded DNA (By similarity); High confidence in function and specificity. | 0.993 |
azo0443 | polA | azo0443 | azo3600 | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.736 |
azo0443 | sbcC | azo0443 | azo0200 | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | Exonuclease SbcC, putative; Nuclease sbcCD subunit C. SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3->5 double strand exonuclease that can open hairpins. It also has a 5 single-strand endonuclease activity (By similarity). sbcc: exonuclease SbcC; High confidence in function and specificity. | 0.584 |
azo0443 | sbcD | azo0443 | azo0199 | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | Exonuclease SbcD, putative; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.673 |
azo0445 | azo0443 | azo0445 | azo0443 | Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity. | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | 0.919 |
azo0445 | azo0446 | azo0445 | azo0446 | Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity. | Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. | 0.956 |
azo0445 | azo1795 | azo0445 | azo1795 | Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity. | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | 0.517 |
azo0445 | lig2 | azo0445 | azo0444 | Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity. | DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]). This protein seals during DNA replication DNA recombination and DNA repair nicks in double-stranded DNA (By similarity); High confidence in function and specificity. | 0.918 |
azo0446 | azo0443 | azo0446 | azo0443 | Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | 0.918 |
azo0446 | azo0445 | azo0446 | azo0445 | Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. | Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity. | 0.956 |
azo0446 | azo1795 | azo0446 | azo1795 | Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | 0.477 |
azo0446 | lig2 | azo0446 | azo0444 | Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. | DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]). This protein seals during DNA replication DNA recombination and DNA repair nicks in double-stranded DNA (By similarity); High confidence in function and specificity. | 0.929 |
azo1795 | azo0443 | azo1795 | azo0443 | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership. | 0.619 |
azo1795 | azo0445 | azo1795 | azo0445 | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity. | 0.517 |
azo1795 | azo0446 | azo1795 | azo0446 | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. | 0.477 |
azo1795 | dnaN | azo1795 | azo0002 | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | 0.548 |
azo1795 | lig2 | azo1795 | azo0444 | Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. | DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]). This protein seals during DNA replication DNA recombination and DNA repair nicks in double-stranded DNA (By similarity); High confidence in function and specificity. | 0.723 |