STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo0446Probable Hypothetical protein MJ0037. Members of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of Escherichia coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal TREMBL:Q88NV2: 46% identity, 59% similarity InterPro:IPR004843; M-ppestrase. Pfam: PF00149; Metallophos; No transmembrane helices TIGR00024: conserved hypothetical prot; Function unclear. (222 aa)    
Predicted Functional Partners:
azo0445
Putative ATP-dependent helicase MTH1802. TREMBL:Q88NV1: 57% identity, 66% similarity InterPro:IPR001410; DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490: HELICc livcs: branched-chain amino acid trans Non secretory protein with low probablity of cleavage site (0.167): Signal P predicted. No transmembrane helices (TMHMM predicted); High confidence in function and specificity.
 
    0.956
lig2
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]). This protein seals during DNA replication DNA recombination and DNA repair nicks in double-stranded DNA (By similarity); High confidence in function and specificity.
 
   
 0.929
azo0443
Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership.
 
     0.918
azo1741
Putative DNA-ligase like protein Rv0938/MT0965. dnl1: DNA ligase I ATP-dependent; Specificity unclear; ORF4.
 
   
 0.581
azo1795
Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear.
  
     0.477
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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