STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
trxB1Putative thioredoxin reductase. Homology to trxB of S. coelicolor of 25% (sprot|TRXB_STRCO). Catalyse the reaction: thioredoxin + nadp(+) = thioredoxin disulfide + nadph. InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327) Pfam: Pyridine nucleotide-disulphide oxidoreductase no signal peptide no TMHs; Family membership. (298 aa)    
Predicted Functional Partners:
ahpC
Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
  
 
 0.937
trxA1
Thioredoxin-disulfide reductase. Homology to trxA of T. ferrooxidans of 69% (THIO_THIFE). Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide. InterPro: Thioredoxin (IPR006662) Pfam: Thioredoxin no signal peptide no TMHs; Specificity unclear.
 
 0.933
trxC1
Probable protein-disulfide reductase. Homology with trxC of E. coli of 45% (AAB88587). Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. InterPro: Thioredoxin Tigrfam: redox_disulf_1: redox-active disulfide Pfam: Thioredoxin no TMHs no signal peptide; Family membership.
 
 0.876
azo2663
Conserved hypothetical peroxiredoxin; Conserve peroxiredoxin. Homology to mll2432 of M. loti of 74% (trembl|Q98IF0). Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic fatty acid and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Pfam: AhpC/TSA family no TMHs. No signal peptide; Family membership.
  
 
 0.869
trxC2
Probable thioredoxin-disulfide reductase. Homology to trxC3 (THI3_CORNE) of C. nephridii of 43%. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Pfam: Thioredoxin no signal peptide no TMHs; Family membership.
  
 0.856
txn
Thioredoxin-disulfide reductase; Putative Thioredoxin. Homology to txn (THIO_ICTPU) of I. punctatus of 36%. Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. InterPro: Thioredoxin (IPR0006662) Tigrfam: dsbE: periplasmic protein thiol:disulfie Oxidoreductase, DSB subfamily Pfam: Thioredoxin no signal peptide no TMHs; Family membership.
  
 0.846
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
    
 0.818
hupG
Hydrogenase-1 operon protein HyaE, 50% similarity to TrEMBL;Q8XGC7, 46% similarity to SwissProt;P19931. Alias: hupG Has PF07449:Hydrogenase-1 expression protein HyaE(IPR010893);This family contains bacterial hydrogenase-1 expression proteins approximately 120 residues long. This includes the E. coli protein HyaE, and the homologous proteins HoxO of R. eutropha and HupG of R. leguminosarum. Deletion of the hoxO gene in R. eutropha led to complete loss of the uptake [NiFe] hydrogenase activity, suggesting that it has a critical role in hydrogenase assembly. No signal peptide or TMH repor [...]
  
 0.809
gcvP
Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
 0.776
nifU
Probable nitrogen fixation protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 
 0.751
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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