STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nifMProbable peptidylprolyl isomerase. Homology with nifM of A. chroococcum of 43% (sprot|NIFM_AZOCH) REQUIRED FOR THE ACTIVATION AND STABILIZATION OF THE IRON-COMPONENT (NIFH) OF NITROGENASE. PROBABLE PPIASE. InterPro: PpiC-type peptidyl-prolyl cis-trans isomerase (IPR000297) Pfam: PPIC-type PPIASE domain no signal peptide no TMHs hydrog_prot: hydrogenase maturation pro; High confidence in function and specificity. (285 aa)    
Predicted Functional Partners:
nifZ
Nitrogen Fixation protein[nifZ], 51% identity (67% similarity) SwissProt;P14889,66% similarity to SwissProt;P23124. Has PF04319:NifZ domain;(IPR007415)This short protein is found in the nif (nitrogen fixation) operon. Its function is unknown but is probably involved in nitrogen fixation or regulating some component of this process. This 75 residue region is presumed to be a domain. It is found in isolation in some members and in the amino terminal half of the longer NifZ proteins. No Signal Peptide Or TMH reported Present; High confidence in function and specificity.
   
 0.953
azo0549
Conserved hypothetical protein. Homology to orf8 of Azotobacter vinelandii of 36% (tremble:Q44542). No domains predicted. No Signal peptide or TMH present.
 
 
   0.844
nifW
Nitrogen fixation protein NifW; May protect the nitrogenase Fe-Mo protein from oxidative damage; Belongs to the NifW family.
 
   
 0.796
nifV
Homocitrate synthase is involved in the biosynthesis of the iron-molybdenum cofactor of nitrogenase and catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate into homocitrate. Similar to sprot|NIFV_AZOVI (51%) and to sprot|NIV1_ANASP (42%). Pfam (PF00682): HMG-CoA Lyase-like family InterPro (PS00815): Alpha-isopropylmalate and homocitrate synthase; High confidence in function and specificity; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
   
 0.756
azo0544
ORF1; Conserved hypothetical protein. Homology to orf1 of Azoarcus sp. BH72 of 100% (gi|11493650|gb|AAG35591.1|(NBCI ENTREZ)). No domains predicted. No TMHs. No signal peptide.
 
     0.719
azo0557
Conserved hypothetical protein Shows similarity to hypothetical 7.7 kDa protein in fixX 3'region (ORF1) of Azorhizobium caulinodans. TIGR00162: conserved hypothetical protein.
 
     0.709
azo0536
Conserved hypothetical protein. Homology to an orf of Pseudomonas stutzeri of 52% (tremble:Q9EVM9). No domains predicted. No TMHs. No signal peptide.
 
     0.698
nifL
Nitrogen fixation regulatory protein (EC 2.7.3.-). Required for the inhibition of nifA activity in response to oxygen and low level of fixed nitrogen. Similar to SWISSPROT: sprot|NIFL_AZOVI (41% Azotobacter vinelandii,nitrogen fixation regulatory protein (EC 2.7.3.-), NifL) InterPro: IPR003661 His_kinA_N. The histidine kinase A (phosphoacceptor) N-terminal domain is a dimerisation and phosphoacceptor domain of histidine kinases. It has been found in bacterial sensor protein/histidine kinases. IPR000014 PAS. PAS domains are involved in many signalling proteins where they are used as a s [...]
  
     0.661
nifP
Serine acetyltransferase (EC 2.3.1.30). Homology to nifP of A. chrooccum of 58% (pir|D43706). PROBABLE SERINE ACETYLTRANSFERASE REQUIRED FOR OPTIMIZING THE EXPRESSION OF NITROGENASE ACTIVITY. NIFP MAY BE REQUIRED TO BOOST RATES OF SYNTHESIS OR INTRACELLULAR CONCENTRATIONS OF CYSTEINE OR METHIONINE. InterPro: Bacterial transferase hexapeptide repeat (IPR001451) no signal peptide no TMHs; High confidence in function and specificity.
     
 0.661
nifU
Probable nitrogen fixation protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
 
  
 0.642
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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