STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo0558Conserved hypothetical protein(Has probable Nif-associated protein function)41% identity(62% similarity) to TrEMBL;Q9KJL5. Has PF03270(IPR004952):Protein of unknown function, DUF269;Members of this family may be involved in nitrogen fixation, since they are found within nitrogen fixation operons. NO Signal Peptide or TMH present; Family membership. (161 aa)    
Predicted Functional Partners:
nifN
Probable nitrogenase iron-molybdenum cofactor biosynthesis protein NifN. Homology to nifN of A. vielandii of 60% (sprot|NIFN_AZOVI). This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor). InterPro: Oxidoreductase nitrogenase component 1 (IPR000510) Pfam: Nitrogenease component 1 type oxidoreductase probable signal peptide no TMHs; High confidence in function and specificity; Belongs to the NifD/NifK/NifE/NifN family.
 
    0.956
nifX
Conserved hypothetical NifX protein. Homology to nifX of Azotobacter vinelandii of 47% (gi|128328|sp|P14887|NIFX_AZOVI(NBCI ENTREZ)). Pfam: Dinitrogenase iron-molybdenum cofactor. This family contains several NIF (B, Y and X) proteins which are involved in the synthesis of an iron-molybdenum cofactors (FeMo-co) in the dinitrogenase enzyme which catalyses the reduction of dinitrogen to ammonium. No signal peptide predicted. No TMHs; Conserved hypothetical protein.
 
  
 0.952
nifE
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE. Homology to nifE of A. vielandii of 70% (sprot|NIFE_AZOVI). This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor). InterPro: Oxidoreductase nitrogenase component 1 (IPR000510) Pfam: Nitrogenease component 1 type oxidoreductase no signal peptide no TMHs; High confidence in function and specificity; Belongs to the NifD/NifK/NifE/NifN family.
 
    0.948
fdxB
Probable ferredoxin. Homology to fdxB of R. capsulatus of 45% (sprot|FER3_RHOCA) Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. InterPro: 4Fe-4S ferredoxin iron-sulfur binding domain (IPR001450) Pfam: 4Fe-4S binding domain no signal peptide no TMHs; Family membership.
 
    0.898
azo0557
Conserved hypothetical protein Shows similarity to hypothetical 7.7 kDa protein in fixX 3'region (ORF1) of Azorhizobium caulinodans. TIGR00162: conserved hypothetical protein.
 
  
 0.896
nifZ
Nitrogen Fixation protein[nifZ], 51% identity (67% similarity) SwissProt;P14889,66% similarity to SwissProt;P23124. Has PF04319:NifZ domain;(IPR007415)This short protein is found in the nif (nitrogen fixation) operon. Its function is unknown but is probably involved in nitrogen fixation or regulating some component of this process. This 75 residue region is presumed to be a domain. It is found in isolation in some members and in the amino terminal half of the longer NifZ proteins. No Signal Peptide Or TMH reported Present; High confidence in function and specificity.
 
    0.876
nifW
Nitrogen fixation protein NifW; May protect the nitrogenase Fe-Mo protein from oxidative damage; Belongs to the NifW family.
 
  
 0.872
nifB
Nitrogen fixation protein; FeMo cofactor biosynthesis protein nifB. PROBABLY INVOLVED IN THE SYNTHESIS OF THE FE-MO COFACTOR; High confidence in function and specificity.
 
  
 0.869
nifT
Nitrogen fixation protein [nifT],51% identity(72% Similarity) to SwissProt;P09427, TrEMBL;Q93JU8,57% identity. Has PF06988:NifT/FixU protein(IPR009727);This family consists of several NifT and FixU bacterial proteins. The function of NifT is unknown although it is thought that the protein may be involved in biosynthesis of the FeMo cofactor of nitrogenase although perturbation of nifT expression in K. pneumoniae has only a limited effect on nitrogen fixation. No Signal peptide or TMH present; High confidence in function and specificity.
 
    0.854
azo0564
Conserved hypothetical protein. Has PF05484:LRV protein FeS4 cluster(IPR008665);This Iron sulphur cluster is found at the N-terminus of some proteins containing LRV repeats. Has 6,(IPR004830) PF01816:Leucine rich repeat variant;The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix,the other is the much rarer 3-10 helix; Function unclear.
 
    0.842
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.