STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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azo0580Putative methyl-accepting chemotaxis transducer,Chmtaxis_transd. Pfam: PF00015; MCPsignal. SMART: SM00283; MA. Signal P reporting signal peptide. TMHMM reporting 1 transmembrane helices. Methyl-accepting chemotaxis serine transducer. CHEMOTACTIC-SIGNAL TRANSDUCERS RESPOND TO CHANGES IN THE CONCENTRATION OF ATTRACTANTS AND REPELLENTS IN THE ENVIRONMENT TRANSDUCE A SIGNAL FROM THE OUTSIDE TO THE INSIDE OF THE CELL AND FACILITATE SENSORY ADAPTATION THROUGH THE VARIATION OF THE LEVEL OF METHYLATION. ATTRACTANTS INCREASE THE LEVEL OF METHYLATION WHILE REPELLENTS DECREASE THE LEVEL OF METHYL [...] (553 aa)    
Predicted Functional Partners:
cheW1
Probable positive regulator of CheA protein activity, CheW. Pfam: PF01584; CheW. SMART: SM00260; CheW. Chemotaxis protein cheW.Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges chea to the mcps (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to cheY and cheB; High confidence in function and specificity.
 
 0.944
cheA1
Putative chemotaxis histidine kinase protein,ATPbind_ATPase. IPR004358; Bact_sens_pr_C. IPR002545; CheW. IPR004105; H-kinase_dim. IPR005467; His_kinase. IPR008207; Hpt. IPR008208; Hpt_N. Pfam: PF01584; CheW. PF02895; H-kinase_dim. PF02518; HATPase_c. PF01627; Hpt. SMART: SM00260; CheW. SM00387; HATPase_c. SM00073; HPT. Chemotaxis protein cheA (EC 2.7.3.-). INVOLVED IN THE TRANSMISSION OF SENSORY SIGNALS FROM THE CHEMORECEPTORS TO THE FLAGELLAR MOTORS. CHEA IS AUTOPHOSPHORYLATED; IT CAN TRANSFER ITS PHOSPHATE GROUP TO EITHER CHEB OR CHEY; High confidence in function and specificity.
 
 0.944
cheA2
Chemotaxis protein cheA; INVOLVED IN THE TRANSMISSION OF SENSORY SIGNALS FROM THE CHEMORECEPTORS TO THE FLAGELLAR MOTORS. CHEA IS AUTOPHOSPHORYLATED; IT CAN TRANSFER ITS PHOSPHATE GROUP TO EITHER CHEB OR CHEY. EMBL AE005411; AAG56878.1; -. AP002559; BAB36021.1; -. PIR B85802; B85802. F90953; F90953. InterPro IPR003594; ATPbind_ATPase. IPR004358; Bact_sens_pr_C. IPR002545; CheW. IPR000629; DEAD_box. IPR004105; H-kinase_dim. IPR005467; His_kinase. IPR009082; His_kin_homodim. IPR008207; Hpt. IPR008208; Hpt_N. Pfam PF01584; CheW; 1. PF02895; H-kinase_dim; 1. PF02518; HATPase_c; 1. PF01627; [...]
 
 0.944
cheA3
Chemotaxis histidine kinase protein,ATPbind_ATPase. IPR004358; Bact_sens_pr_C. IPR002545; CheW. IPR004105; H-kinase_dim. IPR005467; His_kinase. IPR008207; Hpt. IPR008208; Hpt_N. Pfam: PF01584; CheW. PF02895; H-kinase_dim. PF02518; HATPase_c. PF01627; Hpt. SMART: SM00260; CheW. SM00387; HATPase_c. SM00073; HPT. Chemotaxis protein cheA (EC 2.7.3.-). INVOLVED IN THE TRANSMISSION OF SENSORY SIGNALS FROM THE CHEMORECEPTORS TO THE FLAGELLAR MOTORS. CHEA IS AUTOPHOSPHORYLATED; IT CAN TRANSFER ITS PHOSPHATE GROUP TO EITHER CHEB OR CHEY; High confidence in function and specificity.
 
 0.944
cheW2
Positive regulator of CheA protein activity,; High confidence in function and specificity.
 
 0.941
pilL
Putative pilus biogenese protein, ATPbind_ATPase. IPR004358; Bact_sens_pr_C. IPR002545; CheW. IPR004105; H-kinase_dim. IPR005467; His_kinase. IPR008207; Hpt. IPR008208; Hpt_N. IPR001789; Response_reg. Pfam: PF01584; CheW. PF02895; H-kinase_dim. PF02518; HATPase_c. PF01627; Hpt. PF00072; Response_reg. SMART: SM00260; CheW. SM00387; HATPase_c. SM00073; HPT. SM00448; REC. HTH reporting nucleic acid binding motif; Function unclear.
 
 0.909
cheV2
Probable chemotaxis protein, CheW. IPR001789; Response_reg. Pfam: PF01584; CheW. PF00072; Response_reg. SMART: SM00260; CheW. SM00448; REC. Chemotaxis protein cheV. CHEMOTAXIS INVOLVES BOTH A PHOSPHORYLATION-DEPENDENT EXCITATION AND A METHYLATION-DEPENDENT ADAPTATION. CHEV AND CHEW FUNCTION TOGETHER TO COUPLE CHEA ACTIVATION TO METHYL-ACCEPTING CHEMOTAXIS PROTEIN RECEPTOR STATUS AND POSSIBLE CHEA-DEPENDENT PHOSPHORYLATION OF CHEV CONTRIBUTES TO ADAPTATION; High confidence in function and specificity.
 
 0.905
cheR1
Probable chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
 
 0.898
cheR2
Chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
 
 0.893
cheB2
Protein glutamate-methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 0.860
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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