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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (388 aa)    
Predicted Functional Partners:
metH
Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.975
ribH
Riboflavin synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 
 0.936
metF
5,10-methylenetetrahydrofolate reductase (FADH2; 510-methylenetetrahydrofolate reductase InterPro: Methylenetetrahydrofolate reductase fadh2: 510-methylenetetrahydrofolate reductase; High confidence in function and specificity; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.910
tyrB
Probable aromatic-amino-acid aminotransferase. Homology to tyrB of E. coli of 52% (sprot|TYRB_ECO). Is involved in biosynthesis of phe, tyr, asp and leu. Catalyse the reactiion: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + l-glutamate. Pfam: Aminotransferase class I and II no signal peptide no TMHs; High confidence in function and specificity.
     
 0.896
azo2193
Probable O-acetylhomoserine aminocarboxypropyltransferase. Homology to cysD of A. nidulans of 51% (sprot|CYSD_EMENI). Transforms O-acetylhomoserine into homocysteine. Pfam: Cys/Met metabolism PLP-dependent enzyme no signal peptide no TMHs; High confidence in function and specificity.
   
 
 0.892
acyH
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.873
azo1422
Probable O-acetylhomoserine aminocarboxypropyltransferase. Homology with cysD of A. nidulans of 54% (sprot|CYSD_EMENI). Transforms O-acetylhomoserine into homocysteine. InterPro: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes (IPR000277) Pfam: Cys/Met metabolism PLP-dependent enzyme no signal peptide no TMHs; High confidence in function and specificity.
   
 
 0.870
mscL
Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
   
    0.831
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.825
acbB
Putative dTDP-glucose 4-6-dehydratase; dTDP-glucose 4,6-dehydratase, AcbB,probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily. 30% dTDP_gluc_dehyt.IPR001509; Epimerase_Dh. Pfam:PF01370; Epimerase; 1. TIGRFAMs:TIGR01181; dTDP_gluc_dehyt; 1; High confidence in function and specificity.
   
 0.810
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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