node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ilvB | ilvC | azo1034 | azo3156 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.996 |
ilvB | ilvD | azo1034 | azo0632 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. Similar to sprot|ILVD_PSEAE (74%) and sprot|ILVD_ECOL6 (72%). TIGRfam (TIGR00110): Dihydroxy-acid dehydratase Pfam (PF00920): Dihydroxy-acid and 6-phosphogluconate dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. | 0.944 |
ilvB | ilvE1 | azo1034 | azo0133 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.570 |
ilvB | ilvE2 | azo1034 | azo2775 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.574 |
ilvB | ilvI | azo1034 | azo3154 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | Acetolactate synthase isozyme III large subunit (AHAS- III) (Acetohydroxy-acid synthase III large subunit) (ALS-III). InterPro: Acetolactate synthase large subunit biosynthetic type TIGRFAM: acolac_lg: acetolactate synthase large subunit, biosynthetic type; High confidence in function and specificity. | 0.934 |
ilvB | leuA1 | azo1034 | azo3162 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.955 |
ilvB | leuA2 | azo1034 | azo3523 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.953 |
ilvB | leuC | azo1034 | azo1039 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.892 |
ilvB | leuD | azo1034 | azo1040 | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | LeuD protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.885 |
ilvC | ilvB | azo3156 | azo1034 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | 0.996 |
ilvC | ilvD | azo3156 | azo0632 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. Similar to sprot|ILVD_PSEAE (74%) and sprot|ILVD_ECOL6 (72%). TIGRfam (TIGR00110): Dihydroxy-acid dehydratase Pfam (PF00920): Dihydroxy-acid and 6-phosphogluconate dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. | 0.997 |
ilvC | ilvE1 | azo3156 | azo0133 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.524 |
ilvC | ilvE2 | azo3156 | azo2775 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.641 |
ilvC | ilvI | azo3156 | azo3154 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase isozyme III large subunit (AHAS- III) (Acetohydroxy-acid synthase III large subunit) (ALS-III). InterPro: Acetolactate synthase large subunit biosynthetic type TIGRFAM: acolac_lg: acetolactate synthase large subunit, biosynthetic type; High confidence in function and specificity. | 0.997 |
ilvC | leuA1 | azo3156 | azo3162 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.839 |
ilvC | leuA2 | azo3156 | azo3523 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.750 |
ilvC | leuC | azo3156 | azo1039 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.951 |
ilvC | leuD | azo3156 | azo1040 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | LeuD protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.955 |
ilvC | panB | azo3156 | azo3144 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.414 |
ilvD | ilvB | azo0632 | azo1034 | Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. Similar to sprot|ILVD_PSEAE (74%) and sprot|ILVD_ECOL6 (72%). TIGRfam (TIGR00110): Dihydroxy-acid dehydratase Pfam (PF00920): Dihydroxy-acid and 6-phosphogluconate dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. | Acetolactate synthase isozyme I large subunit (AHAS-I) (Acetohydroxy-acid synthase I large subunit) (ALS-I). InterPro: Acetolactate synthase large subunit biosynthetic type acolac_lg: acetolactate synthase large subunit,biosynthetic type; High confidence in function and specificity. | 0.944 |