Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mntB1Putative manganese transport system, permease protein; Part of the ABC transporter complex mntABC involved in manganese import. Probably responsible for the translocation of the substrate across the membrane. Similar to the permease protein, MntB in Synechocystis 6803. 30% IPR001626; ABC_transpt3. Pfam; PF00950; ABC-3; 1. This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity. (294 aa)    
Predicted Functional Partners:
mntA1
Manganese transport system ATP-binding protein mntA. This protein is probably a component of a manganese permease a binding protein-dependent ATP-driven transport system (mntABC). Probably responsible for energy coupling to the transport system. 36% AAA_ATPase.IPR003439,AAA ATPase superfamily; ABC_transporter. Pfam: PF00005; ABC_tran; 1. This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity.
 
 0.998
mntC1
Part of the ABC transporter complex mntABC involved in manganese uptake. 41% Similar to the putative periplasmic-binding protein MntC precursor in E.coli. The MntC protein is also involved in the resistance to oxidative stress in N gonorrhoaeae. TREMBL E.coli:Q9F4F6. InterPro:IPR006128; Lipoprotein_4.IPR006127; SBP_bac_9. Pfam:PF01297; SBP_bac_9; 1. Signal peptide present.TMHelix:1 This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity.
 
 0.997
mntA2
Manganese transport system ATP-binding protein mntA. This protein is probably a component of a manganese permease a binding protein-dependent ATP-driven transport system (mntABC). Probably responsible for energy coupling to the transport system. 40% AAA_ATPase.IPR003439,AAA ATPase superfamily; ABC_transporter. Pfam: PF00005; ABC_tran; 1. This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity.
 
 0.992
mntC2
Putative periplasmic solute binding protein; Part of the ABC transporter complex mntABC involved in manganese uptake. 28% Similar to the putative periplasmic-binding protein MntC precursor in N gonorrhoaeae, also involved in the resistance to oxidative stress. TREMBL:Q9F4F6 InterPro:IPR006128; Lipoprotein_4.IPR006127; SBP_bac_9. Pfam:PF01297; SBP_bac_9; 1. Signal peptide present.TMHelix:1 This operon probably is also involved in other cations uptake like Fe,Cu and Zn.This protein also could act as an adhesin which is involved on adherence to extracellular matrix; High confidence in fun [...]
 
 0.985
azo0644
Putative regulator protein, probably involved in the regulation of cation uptake systems. 32% FUR.IPR009058; Wing_hlx_DNA_bnd. Pfam:PF01475; FUR; 1.Fur family protein 30%; Function unclear.
  
  
 0.847
yhbG
Probable ABC transporter ATP-binding protein HI1148. ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. TREMBL:Q7NST9: 64% identity,75% similarity InterPro: IPR003593; AAA_ATPase. IPR003439; ABC_transporter. IPR000767; Disease_resist. IPR003016; Lipoyl_BS. Pfam PF00005; ABC_tran; 1 mobB: molybdopterin-guanine dinucleoti TMH's present 0; High confidence in function and specificity.
     
 0.846
azo2902
Probable integral membrane protein; TREMBL:Q8XWQ6: 39% identity, 56% similarity Hypothetical protein HI1703. InterPro: IPR005495; YjgP_YjgQ. Pfam: PF03739;Pfam :DUF214:Predicted permease Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long, contain about 6 transmembrane regions and may be permeases, although there is no verification of this. subcellular location:integral membrane protein (potential). similarity:strong, to h.influenzae hi1703 2a69: Auxin Efflux Carrier TMHMM predicted 6 transmembrane helices; Conserved [...]
     
 0.841
azo0807
Conserved hypothetical membrane protein Similar to TREMBL:Q7P0W7 (65% identity); TREMBL:Q82SF6 (65% identity); TREMBL:Q7VSZ9 (57% identity). InterPro (IPR003453): Domain of unknown function DUF140. Pfam (PF02405): Domain of unknown function DUF140. TIGRFAM (TIGR00056): Conserved hypothetical protein. TMHMM reporting five transmembrane helices.
     
 0.836
azo0813
ABC-2 type transporter permease protein; Similar to TREMBL:Q8XV76 (69% identity); TREMBL:Q7P0X7 (66% identity); TREMBL:Q82SG1 (64% identity). InterPro (IPR000412): ABC transporter, family 2. Pfam (PF01061): ABC-2 type transporter. TMHMM reporting seven transmembrane helices. TC (3.A.1): The ATP-binding Cassette (ABC) Superfamily; Specificity unclear.
    
  0.831
azo2910
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q8FZX0 (58% identity); TREMBL:Q8U6Y9 (59% identity). InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). InterPro (IPR003439): ABC transporter. Pfam (PF00005): ABC transpor [...]
    
  0.815
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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