Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mntA1Manganese transport system ATP-binding protein mntA. This protein is probably a component of a manganese permease a binding protein-dependent ATP-driven transport system (mntABC). Probably responsible for energy coupling to the transport system. 36% AAA_ATPase.IPR003439,AAA ATPase superfamily; ABC_transporter. Pfam: PF00005; ABC_tran; 1. This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity. (256 aa)    
Predicted Functional Partners:
mntB1
Putative manganese transport system, permease protein; Part of the ABC transporter complex mntABC involved in manganese import. Probably responsible for the translocation of the substrate across the membrane. Similar to the permease protein, MntB in Synechocystis 6803. 30% IPR001626; ABC_transpt3. Pfam; PF00950; ABC-3; 1. This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity.
 
 0.998
mntB2
Putative manganese transport system permease protein; Part of the ABC transporter complex mntABC involved in manganese import. Probably responsible for the translocation of the substrate across the membrane. 28% IPR001626; ABC_transpt3. Pfam; PF00950; ABC-3; 1. TmHelix:8 This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity.
 
 0.993
mntB3
Putative manganese transport system permease protein; Part of the ABC transporter complex mntABC involved in manganese import. Probably responsible for the translocation of the substrate across the membrane. Similar to the permease protein, MntB in Synechocystis 6803. 30% IPR001626; ABC_transpt3. Pfam; PF00950; ABC-3; 1. This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity.
 
 0.993
mntC1
Part of the ABC transporter complex mntABC involved in manganese uptake. 41% Similar to the putative periplasmic-binding protein MntC precursor in E.coli. The MntC protein is also involved in the resistance to oxidative stress in N gonorrhoaeae. TREMBL E.coli:Q9F4F6. InterPro:IPR006128; Lipoprotein_4.IPR006127; SBP_bac_9. Pfam:PF01297; SBP_bac_9; 1. Signal peptide present.TMHelix:1 This operon probably is also involved in other cations uptake like Fe,Cu and Zn; High confidence in function and specificity.
 
 
 0.990
mntC2
Putative periplasmic solute binding protein; Part of the ABC transporter complex mntABC involved in manganese uptake. 28% Similar to the putative periplasmic-binding protein MntC precursor in N gonorrhoaeae, also involved in the resistance to oxidative stress. TREMBL:Q9F4F6 InterPro:IPR006128; Lipoprotein_4.IPR006127; SBP_bac_9. Pfam:PF01297; SBP_bac_9; 1. Signal peptide present.TMHelix:1 This operon probably is also involved in other cations uptake like Fe,Cu and Zn.This protein also could act as an adhesin which is involved on adherence to extracellular matrix; High confidence in fun [...]
 
 
 0.960
azo0644
Putative regulator protein, probably involved in the regulation of cation uptake systems. 32% FUR.IPR009058; Wing_hlx_DNA_bnd. Pfam:PF01475; FUR; 1.Fur family protein 30%; Function unclear.
  
  
 0.861
azo2910
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q8FZX0 (58% identity); TREMBL:Q8U6Y9 (59% identity). InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). InterPro (IPR003439): ABC transporter. Pfam (PF00005): ABC transpor [...]
    
  0.826
azo0643
Conserved hypothetical membrane protein. Homology to ebA1811 of Azoarcus sp. EbN1 of 38% (gi|56476415|ref|YP_158004.1|(NBCI ENTREZ)). no domains predicted. no signal peptide. 1 TMH; Conserved hypothetical protein.
       0.773
azo3553
Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity.
  
  
0.773
cbiO
Putative cobalt transport system ATP-binding protein; Part of the ABC transporter complex cbiKMQO involved in cobalt import. Probably responsible for the translocation of the substrate across the membrane. 40% AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1. ProDom; PD000006; ABC_transporter; 1. SMART; SM00382; AAA; 1; High confidence in function and specificity.
     
 0.743
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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